| SP | Martinez, P.Martinez, Pedro # >> | 26 | 1997 | R | 91 | 10 | 10 | 6 | 1 | 3.18 | .266 | 1.05 | 6.7 | 2.8 | 10.7 | 70.2 | 52 | 25 | 25 | 5 | 22 | 83 | 4 | 0 | 0 | 1 | 6 | 3 | 2 | 2.63 |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 96 | 10 | 10 | 6 | 2 | 3.08 | .273 | 1.13 | 7.8 | 2.4 | 8.3 | 61.1 | 53 | 21 | 21 | 7 | 16 | 56 | 1 | 0 | 0 | 1 | 7 | 0 | 0 | 3.44 |
| SP | Nabholz, C.Nabholz, Chris >> | 23 | 1990 | L | 70 | 10 | 10 | 0 | 1 | 1.85 | .311 | 1.36 | 6.0 | 6.4 | 8.3 | 24.1 | 16 | 7 | 5 | 0 | 17 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.29 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 73 | 9 | 9 | 4 | 5 | 4.24 | .292 | 1.19 | 8.2 | 2.5 | 5.8 | 57.1 | 52 | 31 | 27 | 9 | 16 | 37 | 1 | 0 | 0 | 0 | 6 | 3 | 0 | 4.75 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 62 | 9 | 9 | 6 | 1 | 3.50 | .308 | 1.28 | 8.3 | 3.2 | 8.2 | 54.0 | 50 | 21 | 21 | 5 | 19 | 49 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 3.61 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 100 | 26 | 0 | 1 | 1 | 3.00 | .255 | 0.97 | 6.2 | 2.5 | 8.5 | 39.0 | 27 | 13 | 13 | 3 | 11 | 37 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.10 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 82 | 19 | 0 | 1 | 0 | 2.63 | .248 | 0.99 | 5.7 | 3.3 | 8.3 | 27.1 | 17 | 8 | 8 | 4 | 10 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 81 | 24 | 0 | 3 | 2 | 5.59 | .331 | 1.48 | 10.6 | 2.8 | 9.3 | 29.0 | 34 | 19 | 18 | 8 | 9 | 30 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 5.45 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 88 | 16 | 0 | 5 | 1 | 1.86 | .216 | 0.83 | 6.2 | 1.2 | 4.7 | 29.0 | 20 | 6 | 6 | 1 | 4 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.83 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 78 | 13 | 0 | 1 | 0 | 4.40 | .232 | 0.91 | 6.4 | 1.9 | 8.4 | 14.1 | 10 | 7 | 7 | 3 | 3 | 13 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.57 |
| RP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 45 | 8 | 0 | 0 | 0 | 2.57 | .300 | 1.29 | 6.4 | 5.1 | 1.3 | 14.0 | 10 | 4 | 4 | 0 | 8 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.43 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 60 | 13 | 0 | 0 | 1 | 6.00 | .286 | 1.20 | 8.4 | 2.4 | 8.4 | 15.0 | 14 | 10 | 10 | 5 | 4 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.27 |