| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 83 | 21 | 21 | 10 | 5 | 4.03 | .297 | 1.25 | 8.6 | 2.6 | 6.5 | 154.0 | 148 | 72 | 69 | 21 | 44 | 111 | 7 | 0 | 0 | 3 | 11 | 3 | 1 | 4.25 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 89 | 20 | 20 | 9 | 8 | 3.69 | .287 | 1.17 | 8.6 | 2.0 | 8.3 | 126.2 | 120 | 57 | 52 | 14 | 28 | 116 | 0 | 0 | 0 | 0 | 12 | 5 | 1 | 3.39 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 80 | 20 | 20 | 9 | 6 | 4.11 | .299 | 1.26 | 8.9 | 2.5 | 9.2 | 133.2 | 131 | 64 | 61 | 22 | 37 | 136 | 2 | 0 | 0 | 1 | 12 | 3 | 3 | 4.01 |
| SP | Lolich, M.Lolich, Mickey # >> | 28 | 1968 | L | 45 | 19 | 19 | 5 | 10 | 7.25 | .357 | 1.63 | 12.4 | 2.3 | 6.5 | 94.1 | 130 | 77 | 76 | 21 | 24 | 68 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 5.32 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 76 | 55 | 0 | 6 | 0 | 3.84 | .308 | 1.32 | 7.3 | 4.8 | 8.8 | 72.2 | 58 | 34 | 31 | 5 | 38 | 70 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 3.58 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 71 | 42 | 0 | 2 | 2 | 3.94 | .344 | 1.58 | 9.2 | 5.2 | 10.6 | 45.2 | 46 | 21 | 20 | 5 | 26 | 53 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.82 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 62 | 37 | 0 | 2 | 4 | 2.95 | .304 | 1.24 | 6.5 | 4.6 | 6.9 | 55.0 | 40 | 18 | 18 | 5 | 28 | 42 | 0 | 8 | 2 | 0 | 0 | 4 | 3 | 4.40 |
| RP | Alburquerque, A.Alburquerque, Al >> | 25 | 2011 | R | 52 | 28 | 0 | 3 | 2 | 4.80 | .388 | 1.87 | 6.9 | 9.9 | 10.5 | 30.0 | 23 | 17 | 16 | 2 | 33 | 35 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.93 |
| RP | Miller, S.Miller, Shelby >> | 33 | 2024 | R | 34 | 23 | 0 | 1 | 0 | 3.03 | .246 | 0.98 | 7.4 | 1.6 | 6.5 | 29.2 | 24 | 11 | 10 | 2 | 5 | 21 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 2.97 |
| RP | Lasher, F.Lasher, Fred >> | 26 | 1967 | R | 20 | 30 | 0 | 3 | 1 | 3.42 | .319 | 1.39 | 10.0 | 2.6 | 5.9 | 52.2 | 58 | 20 | 20 | 3 | 15 | 34 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.37 |