| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 33 | 33 | 12 | 14 | 4.17 | .285 | 1.18 | 8.1 | 2.5 | 5.4 | 235.0 | 211 | 115 | 109 | 36 | 66 | 142 | 4 | 0 | 0 | 2 | 20 | 4 | 3 | 4.68 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 32 | 32 | 8 | 15 | 5.20 | .310 | 1.32 | 8.7 | 3.2 | 7.5 | 204.1 | 198 | 120 | 118 | 35 | 72 | 170 | 4 | 0 | 0 | 1 | 17 | 5 | 9 | 4.70 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 31 | 8 | 18 | 6.28 | .362 | 1.69 | 10.1 | 5.1 | 8.0 | 169.0 | 190 | 121 | 118 | 28 | 95 | 151 | 0 | 0 | 0 | 0 | 13 | 3 | 3 | 5.11 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 52 | 0 | 7 | 10 | 4.74 | .324 | 1.42 | 6.8 | 6.1 | 11.2 | 49.1 | 37 | 27 | 26 | 8 | 33 | 61 | 0 | 24 | 5 | 0 | 0 | 1 | 0 | 4.71 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 71 | 0 | 2 | 4 | 3.14 | .290 | 1.21 | 8.3 | 2.6 | 8.7 | 66.0 | 61 | 24 | 23 | 12 | 19 | 64 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.33 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 41 | 0 | 5 | 0 | 2.06 | .271 | 1.06 | 4.6 | 4.9 | 8.2 | 35.0 | 18 | 11 | 8 | 1 | 19 | 32 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.34 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 26 | 0 | 1 | 1 | 3.67 | .283 | 1.19 | 6.7 | 4.0 | 9.3 | 27.0 | 20 | 11 | 11 | 6 | 12 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.15 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 28 | 0 | 1 | 0 | 5.00 | .331 | 1.48 | 9.7 | 3.7 | 6.0 | 27.0 | 29 | 16 | 15 | 9 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.22 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 26 | 2 | 0 | 2 | 6.82 | .375 | 1.77 | 12.3 | 3.7 | 5.5 | 101.2 | 138 | 78 | 77 | 17 | 42 | 62 | 0 | 0 | 0 | 0 | 1 | 3 | 6 | 5.30 |