| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 33 | 32 | 7 | 19 | 4.84 | .338 | 1.50 | 9.9 | 3.7 | 5.6 | 210.0 | 230 | 118 | 113 | 29 | 86 | 131 | 3 | 0 | 0 | 1 | 16 | 5 | 3 | 4.85 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 31 | 31 | 5 | 13 | 6.31 | .365 | 1.70 | 11.4 | 4.0 | 5.3 | 189.2 | 239 | 142 | 133 | 24 | 83 | 111 | 3 | 0 | 0 | 0 | 8 | 5 | 7 | 4.87 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 83 | 0 | 6 | 3 | 4.47 | .311 | 1.35 | 8.3 | 3.9 | 7.1 | 110.2 | 101 | 55 | 55 | 14 | 48 | 87 | 0 | 6 | 1 | 0 | 0 | 1 | 6 | 4.41 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 81 | 0 | 7 | 2 | 3.25 | .267 | 1.08 | 7.5 | 2.3 | 7.7 | 105.1 | 87 | 38 | 38 | 10 | 27 | 90 | 0 | 7 | 4 | 0 | 0 | 1 | 5 | 3.32 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 65 | 0 | 4 | 6 | 2.68 | .284 | 1.13 | 7.3 | 2.9 | 9.1 | 84.0 | 68 | 26 | 25 | 8 | 27 | 85 | 0 | 6 | 4 | 0 | 0 | 5 | 4 | 3.36 |
| RP | Dibble, R.Dibble, Rob # >> | 26 | 1990 | R | 57 | 53 | 0 | 1 | 3 | 4.68 | .324 | 1.43 | 8.9 | 4.0 | 9.1 | 67.1 | 66 | 35 | 35 | 5 | 30 | 68 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 3.33 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 3 | 2 | 0 | 2 | 4.63 | .327 | 1.46 | 9.0 | 4.9 | 8.2 | 11.2 | 11 | 7 | 6 | 2 | 6 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.18 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 33 | 1 | 4 | 11 | 4.63 | .364 | 1.68 | 11.3 | 3.9 | 4.7 | 58.1 | 73 | 30 | 30 | 7 | 25 | 30 | 1 | 3 | 3 | 0 | 1 | 2 | 1 | 4.93 |