| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 24 | 24 | 9 | 8 | 3.94 | .323 | 1.40 | 8.9 | 3.6 | 8.7 | 162.0 | 161 | 75 | 71 | 10 | 65 | 156 | 2 | 0 | 0 | 0 | 13 | 6 | 4 | 3.19 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 24 | 24 | 7 | 14 | 5.66 | .341 | 1.53 | 11.3 | 2.5 | 5.1 | 146.1 | 183 | 98 | 92 | 19 | 41 | 82 | 2 | 0 | 0 | 1 | 10 | 3 | 1 | 4.47 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 24 | 24 | 9 | 9 | 4.04 | .279 | 1.14 | 7.8 | 2.5 | 8.0 | 164.2 | 143 | 77 | 74 | 17 | 45 | 145 | 4 | 0 | 0 | 1 | 13 | 3 | 4 | 3.46 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 23 | 23 | 12 | 5 | 3.41 | .311 | 1.36 | 7.4 | 4.8 | 7.4 | 142.1 | 117 | 60 | 54 | 16 | 76 | 117 | 0 | 0 | 0 | 0 | 14 | 0 | 2 | 4.42 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 34 | 0 | 3 | 3 | 2.76 | .310 | 1.29 | 5.1 | 6.8 | 9.8 | 32.2 | 18 | 11 | 10 | 1 | 24 | 35 | 0 | 21 | 4 | 0 | 0 | 2 | 0 | 3.66 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 58 | 0 | 5 | 5 | 3.67 | .321 | 1.40 | 9.4 | 3.2 | 9.3 | 61.1 | 64 | 28 | 25 | 7 | 22 | 63 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 3.56 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 39 | 0 | 3 | 1 | 2.27 | .264 | 1.08 | 6.5 | 3.3 | 8.6 | 43.2 | 31 | 11 | 11 | 3 | 16 | 41 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.12 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 30 | 0 | 0 | 1 | 3.98 | .331 | 1.48 | 9.3 | 4.4 | 9.3 | 31.2 | 32 | 14 | 14 | 4 | 15 | 32 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.06 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 13 | 1 | 0 | 0 | 6.37 | .366 | 1.70 | 10.7 | 4.8 | 5.3 | 53.2 | 63 | 40 | 38 | 11 | 28 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 6.23 |