| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 34 | 34 | 16 | 15 | 3.92 | .312 | 1.33 | 8.9 | 3.2 | 8.2 | 268.2 | 264 | 125 | 117 | 33 | 94 | 245 | 13 | 0 | 0 | 0 | 19 | 7 | 8 | 3.90 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 7 | 19 | 6.11 | .348 | 1.58 | 10.1 | 4.2 | 8.7 | 210.2 | 236 | 152 | 143 | 36 | 97 | 203 | 1 | 0 | 0 | 0 | 11 | 4 | 5 | 4.74 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 73 | 32 | 32 | 15 | 12 | 3.93 | .301 | 1.29 | 8.4 | 3.2 | 4.7 | 249.1 | 233 | 114 | 109 | 27 | 88 | 131 | 16 | 0 | 0 | 1 | 16 | 1 | 1 | 4.43 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 78 | 0 | 2 | 5 | 3.71 | .289 | 1.20 | 7.7 | 3.1 | 9.6 | 104.1 | 89 | 46 | 43 | 11 | 36 | 111 | 0 | 4 | 3 | 0 | 0 | 2 | 3 | 3.34 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 87 | 66 | 0 | 3 | 2 | 4.14 | .285 | 1.17 | 7.2 | 3.3 | 8.8 | 76.0 | 61 | 36 | 35 | 11 | 28 | 74 | 0 | 8 | 5 | 0 | 0 | 2 | 2 | 4.12 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 58 | 0 | 6 | 0 | 3.08 | .324 | 1.41 | 7.6 | 5.1 | 7.0 | 73.0 | 62 | 29 | 25 | 13 | 41 | 57 | 0 | 4 | 2 | 0 | 0 | 2 | 4 | 5.52 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 49 | 0 | 5 | 6 | 4.22 | .304 | 1.28 | 5.9 | 5.6 | 10.4 | 53.1 | 35 | 30 | 25 | 7 | 33 | 61 | 0 | 5 | 2 | 0 | 0 | 2 | 3 | 4.40 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 44 | 0 | 1 | 0 | 2.68 | .295 | 1.23 | 7.3 | 3.8 | 8.0 | 47.0 | 38 | 16 | 14 | 5 | 20 | 42 | 0 | 2 | 1 | 0 | 0 | 1 | 5 | 3.94 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 12 | 0 | 1 | 2 | 3.00 | .308 | 1.33 | 9.0 | 3.0 | 3.5 | 18.0 | 18 | 6 | 6 | 0 | 6 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.22 |