| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 25 | 25 | 6 | 12 | 3.93 | .316 | 1.36 | 9.1 | 3.2 | 8.5 | 167.1 | 168 | 83 | 73 | 17 | 59 | 158 | 2 | 0 | 0 | 2 | 15 | 5 | 1 | 3.58 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 24 | 24 | 9 | 8 | 4.94 | .319 | 1.38 | 8.9 | 3.5 | 6.9 | 155.0 | 154 | 88 | 85 | 21 | 60 | 119 | 2 | 0 | 0 | 1 | 10 | 4 | 6 | 4.46 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 23 | 23 | 9 | 8 | 3.85 | .292 | 1.21 | 7.8 | 3.1 | 7.1 | 170.2 | 148 | 74 | 73 | 18 | 59 | 134 | 5 | 0 | 0 | 2 | 12 | 4 | 4 | 3.91 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 62 | 0 | 4 | 5 | 4.20 | .303 | 1.27 | 8.5 | 3.0 | 8.9 | 83.2 | 78 | 39 | 39 | 9 | 28 | 82 | 0 | 7 | 4 | 0 | 0 | 3 | 1 | 3.55 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 86 | 60 | 0 | 5 | 4 | 8.07 | .394 | 1.91 | 12.7 | 4.5 | 9.3 | 58.0 | 82 | 55 | 52 | 9 | 29 | 60 | 0 | 2 | 5 | 0 | 0 | 2 | 6 | 4.55 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 48 | 0 | 3 | 2 | 4.75 | .356 | 1.60 | 8.5 | 5.9 | 8.0 | 53.0 | 50 | 28 | 28 | 3 | 35 | 47 | 0 | 8 | 3 | 0 | 0 | 3 | 2 | 4.11 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 32 | 0 | 1 | 1 | 3.52 | .286 | 1.17 | 5.4 | 5.2 | 8.1 | 38.1 | 23 | 16 | 15 | 3 | 22 | 34 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.05 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 31 | 0 | 0 | 3 | 4.46 | .335 | 1.44 | 7.7 | 5.4 | 11.3 | 40.1 | 34 | 22 | 20 | 6 | 24 | 50 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 4.48 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 17 | 0 | 2 | 5 | 4.08 | .333 | 1.47 | 8.7 | 4.8 | 5.1 | 28.2 | 27 | 13 | 13 | 4 | 15 | 16 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.43 |