| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 37 | 37 | 17 | 11 | 3.71 | .275 | 1.13 | 7.9 | 2.3 | 8.1 | 252.0 | 221 | 108 | 104 | 22 | 64 | 228 | 0 | 0 | 0 | 0 | 24 | 2 | 0 | 3.11 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 32 | 32 | 8 | 14 | 4.69 | .311 | 1.34 | 9.0 | 3.1 | 6.3 | 203.1 | 202 | 117 | 106 | 27 | 71 | 143 | 1 | 0 | 0 | 0 | 17 | 2 | 7 | 4.40 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 35 | 35 | 9 | 16 | 4.88 | .326 | 1.43 | 8.4 | 4.4 | 7.2 | 214.0 | 200 | 127 | 116 | 31 | 105 | 172 | 0 | 0 | 0 | 0 | 16 | 6 | 3 | 4.83 |
| RP | Gagne, E.Gagne, Eric # >> | 27 | 2003 | R | 98 | 93 | 0 | 1 | 7 | 2.79 | .249 | 0.97 | 6.3 | 2.4 | 8.7 | 129.0 | 90 | 40 | 40 | 10 | 35 | 124 | 0 | 0 | 5 | 0 | 0 | 3 | 7 | 2.97 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 75 | 0 | 9 | 4 | 2.99 | .237 | 0.91 | 6.1 | 2.1 | 9.5 | 90.1 | 61 | 31 | 30 | 12 | 21 | 95 | 0 | 0 | 2 | 0 | 0 | 2 | 4 | 3.39 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 44 | 0 | 5 | 1 | 2.82 | .298 | 1.27 | 7.8 | 3.7 | 5.6 | 51.0 | 44 | 16 | 16 | 7 | 21 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 4.76 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 30 | 0 | 3 | 2 | 2.62 | .259 | 1.02 | 5.0 | 4.2 | 7.7 | 34.1 | 19 | 10 | 10 | 6 | 16 | 29 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.09 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 22 | 0 | 0 | 0 | 2.19 | .321 | 1.42 | 9.4 | 3.8 | 5.6 | 24.2 | 25 | 10 | 6 | 1 | 10 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.54 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 34 | 33 | 16 | 10 | 3.82 | .308 | 1.31 | 7.6 | 4.2 | 7.4 | 224.0 | 189 | 98 | 95 | 19 | 105 | 183 | 1 | 0 | 0 | 0 | 20 | 5 | 15 | 3.94 |