| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 15 | 11 | 3.99 | .285 | 1.18 | 8.6 | 2.0 | 7.9 | 248.0 | 238 | 121 | 110 | 36 | 54 | 218 | 4 | 0 | 0 | 0 | 20 | 4 | 7 | 3.83 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 33 | 33 | 13 | 12 | 3.79 | .310 | 1.33 | 7.9 | 4.1 | 5.6 | 204.0 | 178 | 93 | 86 | 17 | 94 | 126 | 1 | 0 | 0 | 1 | 18 | 3 | 1 | 4.27 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 32 | 32 | 13 | 8 | 4.63 | .333 | 1.49 | 10.6 | 2.9 | 8.0 | 202.1 | 237 | 116 | 104 | 24 | 65 | 180 | 1 | 0 | 0 | 1 | 16 | 1 | 0 | 3.74 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 30 | 30 | 8 | 17 | 7.25 | .380 | 1.82 | 12.7 | 3.7 | 4.3 | 175.0 | 247 | 151 | 141 | 25 | 72 | 84 | 2 | 0 | 0 | 0 | 5 | 3 | 9 | 5.18 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 89 | 0 | 9 | 3 | 3.20 | .275 | 1.11 | 7.1 | 3.0 | 9.6 | 112.1 | 88 | 44 | 40 | 11 | 37 | 119 | 0 | 11 | 1 | 0 | 0 | 3 | 1 | 3.22 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 50 | 0 | 2 | 6 | 3.12 | .295 | 1.24 | 7.8 | 3.5 | 8.6 | 60.2 | 52 | 25 | 21 | 4 | 23 | 57 | 0 | 9 | 3 | 0 | 0 | 1 | 0 | 3.17 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 27 | 0 | 2 | 2 | 2.96 | .305 | 1.32 | 8.6 | 3.4 | 9.4 | 24.1 | 23 | 8 | 8 | 4 | 9 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.21 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 13 | 0 | 0 | 1 | 5.52 | .343 | 1.57 | 9.6 | 5.1 | 8.4 | 14.2 | 15 | 9 | 9 | 2 | 8 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.71 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 18 | 1 | 5 | 2 | 4.25 | .319 | 1.40 | 8.7 | 3.8 | 3.1 | 106.0 | 103 | 54 | 50 | 9 | 45 | 37 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 4.71 |