| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 23 | 23 | 9 | 8 | 4.25 | .291 | 1.21 | 8.7 | 2.2 | 8.0 | 148.1 | 143 | 72 | 70 | 23 | 36 | 132 | 0 | 0 | 0 | 0 | 12 | 4 | 0 | 4.05 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 24 | 24 | 9 | 8 | 4.22 | .335 | 1.50 | 8.8 | 4.8 | 7.7 | 157.2 | 153 | 76 | 74 | 15 | 83 | 135 | 1 | 0 | 0 | 0 | 11 | 2 | 2 | 4.15 |
| SP | Mathewson, C.Mathewson, Christy † # >> | 28 | 1908 | R | 82 | 25 | 24 | 16 | 8 | 3.60 | .267 | 1.08 | 8.1 | 1.7 | 4.8 | 185.0 | 166 | 80 | 74 | 17 | 34 | 99 | 9 | 0 | 0 | 2 | 15 | 2 | 0 | 3.71 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 24 | 24 | 11 | 9 | 5.42 | .322 | 1.41 | 10.0 | 2.7 | 5.0 | 164.1 | 182 | 104 | 99 | 26 | 49 | 91 | 2 | 0 | 0 | 1 | 10 | 3 | 4 | 4.90 |
| RP | Percival, T.Percival, Troy # >> | 26 | 1995 | R | 82 | 47 | 0 | 3 | 3 | 4.79 | .332 | 1.47 | 8.8 | 4.4 | 7.9 | 47.0 | 46 | 26 | 25 | 9 | 23 | 41 | 0 | 7 | 3 | 0 | 0 | 1 | 2 | 5.28 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 26 | 0 | 2 | 1 | 3.43 | .272 | 1.12 | 6.9 | 3.2 | 3.0 | 39.1 | 30 | 18 | 15 | 7 | 14 | 13 | 0 | 5 | 2 | 0 | 0 | 0 | 4 | 5.74 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 4 | 2 | 1 | 2 | 6.75 | .392 | 1.94 | 12.9 | 4.5 | 5.6 | 16.0 | 23 | 12 | 12 | 3 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.69 |