| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 9 | 15 | 4.35 | .315 | 1.38 | 8.3 | 4.1 | 8.9 | 217.0 | 200 | 112 | 105 | 30 | 99 | 214 | 0 | 0 | 0 | 0 | 17 | 1 | 4 | 4.21 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 33 | 33 | 12 | 17 | 4.02 | .304 | 1.29 | 8.7 | 2.9 | 5.7 | 232.2 | 225 | 108 | 104 | 30 | 74 | 146 | 3 | 0 | 0 | 1 | 19 | 6 | 6 | 4.46 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 32 | 11 | 15 | 4.54 | .326 | 1.42 | 9.3 | 3.5 | 4.2 | 206.1 | 212 | 111 | 104 | 19 | 81 | 97 | 4 | 0 | 0 | 3 | 14 | 6 | 2 | 4.52 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 32 | 32 | 8 | 19 | 5.71 | .341 | 1.55 | 10.4 | 3.6 | 5.3 | 206.1 | 237 | 141 | 131 | 41 | 82 | 121 | 3 | 0 | 0 | 0 | 10 | 2 | 5 | 5.64 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 47 | 31 | 31 | 10 | 12 | 5.84 | .334 | 1.49 | 10.5 | 3.0 | 4.8 | 189.2 | 220 | 130 | 123 | 30 | 62 | 100 | 2 | 0 | 0 | 0 | 13 | 3 | 7 | 5.04 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 74 | 0 | 0 | 4 | 3.57 | .310 | 1.35 | 6.0 | 6.2 | 10.0 | 75.2 | 50 | 30 | 30 | 2 | 52 | 83 | 0 | 4 | 2 | 0 | 0 | 0 | 5 | 3.21 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 59 | 0 | 3 | 3 | 3.32 | .295 | 1.26 | 7.6 | 3.8 | 9.2 | 59.2 | 50 | 23 | 22 | 6 | 25 | 60 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.56 |
| CL | Bautista, F.Bautista, Félix † >> | 28 | 2023 | R | 75 | 70 | 0 | 3 | 9 | 4.57 | .330 | 1.45 | 6.8 | 6.2 | 9.1 | 65.0 | 49 | 37 | 33 | 8 | 45 | 66 | 0 | 37 | 5 | 0 | 0 | 2 | 5 | 4.74 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 49 | 0 | 4 | 1 | 4.09 | .288 | 1.18 | 7.8 | 2.9 | 4.6 | 101.1 | 88 | 49 | 46 | 11 | 32 | 52 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 4.43 |