| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 34 | 34 | 3 | 10 | 3.60 | .293 | 1.23 | 7.5 | 3.5 | 8.7 | 160.0 | 134 | 66 | 64 | 22 | 62 | 155 | 0 | 0 | 0 | 0 | 3 | 3 | 8 | 4.07 |
| SP | Sabathia, C.Sabathia, CC # >> | 28 | 2008 | L | 60 | 32 | 32 | 10 | 15 | 5.92 | .333 | 1.47 | 10.2 | 3.0 | 8.3 | 216.0 | 244 | 146 | 142 | 41 | 73 | 198 | 3 | 0 | 0 | 1 | 10 | 7 | 5 | 4.75 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 32 | 32 | 11 | 15 | 5.12 | .327 | 1.42 | 10.0 | 2.8 | 6.3 | 226.2 | 252 | 129 | 129 | 40 | 70 | 157 | 5 | 0 | 0 | 2 | 13 | 8 | 3 | 4.95 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 31 | 31 | 10 | 13 | 4.27 | .319 | 1.36 | 9.6 | 2.7 | 6.5 | 217.1 | 231 | 109 | 103 | 28 | 65 | 156 | 2 | 0 | 0 | 0 | 17 | 9 | 4 | 4.26 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 89 | 0 | 9 | 6 | 2.09 | .255 | 0.97 | 6.4 | 2.4 | 9.7 | 133.2 | 94 | 32 | 31 | 7 | 35 | 144 | 0 | 9 | 5 | 0 | 0 | 8 | 0 | 2.49 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 72 | 0 | 5 | 5 | 3.88 | .296 | 1.24 | 6.2 | 5.0 | 10.7 | 95.0 | 65 | 42 | 41 | 11 | 53 | 113 | 0 | 5 | 3 | 0 | 0 | 2 | 5 | 3.86 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 64 | 0 | 9 | 3 | 3.34 | .298 | 1.27 | 8.1 | 3.5 | 6.9 | 86.1 | 77 | 32 | 32 | 10 | 33 | 66 | 0 | 8 | 5 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 47 | 0 | 5 | 2 | 3.74 | .346 | 1.57 | 10.7 | 3.4 | 7.3 | 53.0 | 63 | 23 | 22 | 10 | 20 | 43 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 5.02 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 43 | 0 | 3 | 0 | 4.11 | .329 | 1.47 | 9.0 | 4.3 | 9.5 | 50.1 | 50 | 24 | 23 | 1 | 24 | 53 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 2.58 |