| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 100 | 35 | 35 | 17 | 14 | 3.87 | .297 | 1.26 | 8.6 | 2.7 | 9.6 | 223.0 | 214 | 98 | 96 | 29 | 66 | 237 | 6 | 0 | 0 | 2 | 21 | 3 | 3 | 3.49 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 87 | 33 | 33 | 16 | 10 | 2.99 | .271 | 1.06 | 7.4 | 2.2 | 5.7 | 240.2 | 197 | 92 | 80 | 24 | 58 | 152 | 10 | 0 | 0 | 4 | 25 | 13 | 6 | 3.92 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 80 | 32 | 32 | 16 | 9 | 4.24 | .311 | 1.31 | 9.1 | 2.7 | 9.3 | 178.1 | 179 | 86 | 84 | 28 | 54 | 183 | 0 | 0 | 0 | 0 | 17 | 8 | 2 | 4.03 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 32 | 32 | 13 | 8 | 4.90 | .336 | 1.48 | 8.6 | 4.9 | 6.8 | 161.2 | 153 | 93 | 88 | 25 | 87 | 122 | 2 | 0 | 0 | 2 | 13 | 5 | 4 | 5.22 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 69 | 31 | 31 | 15 | 7 | 3.83 | .308 | 1.31 | 8.4 | 3.4 | 8.6 | 211.2 | 198 | 97 | 90 | 25 | 80 | 202 | 2 | 0 | 0 | 0 | 19 | 5 | 2 | 3.83 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 75 | 0 | 5 | 1 | 3.52 | .309 | 1.34 | 8.8 | 3.3 | 8.6 | 107.1 | 105 | 43 | 42 | 12 | 39 | 102 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.64 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 70 | 0 | 2 | 3 | 2.55 | .247 | 0.96 | 7.1 | 1.6 | 9.0 | 88.1 | 69 | 28 | 25 | 11 | 16 | 88 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.24 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 54 | 0 | 6 | 4 | 3.26 | .287 | 1.16 | 7.6 | 2.9 | 8.0 | 66.1 | 56 | 24 | 24 | 3 | 21 | 59 | 0 | 1 | 2 | 0 | 0 | 3 | 3 | 2.89 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 79 | 39 | 0 | 3 | 4 | 1.98 | .231 | 0.84 | 4.5 | 3.1 | 8.3 | 50.0 | 25 | 11 | 11 | 4 | 17 | 46 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.40 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 76 | 21 | 0 | 1 | 2 | 3.75 | .314 | 1.29 | 6.8 | 4.9 | 9.0 | 24.0 | 18 | 11 | 10 | 4 | 13 | 24 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.04 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 29 | 0 | 1 | 0 | 1.46 | .218 | 0.81 | 4.4 | 2.9 | 9.2 | 37.0 | 18 | 6 | 6 | 1 | 12 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.35 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 60 | 0 | 1 | 5 | 4.10 | .302 | 1.28 | 8.7 | 2.9 | 9.9 | 59.1 | 57 | 33 | 27 | 8 | 19 | 65 | 0 | 38 | 5 | 0 | 0 | 1 | 0 | 3.58 |