| SP | Sheets, B.Sheets, Ben † $$ >> | 26 | 2004 | R | 90 | 34 | 34 | 15 | 12 | 3.72 | .278 | 1.14 | 8.8 | 1.5 | 9.1 | 232.1 | 226 | 98 | 96 | 25 | 38 | 234 | 4 | 0 | 0 | 1 | 23 | 4 | 2 | 2.93 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 34 | 33 | 11 | 9 | 4.16 | .291 | 1.20 | 8.5 | 2.4 | 6.4 | 166.2 | 156 | 80 | 77 | 23 | 44 | 118 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 4.27 |
| SP | Hernandez, F.Hernandez, Felix # >> | 19 | 2005 | R | 96 | 33 | 32 | 16 | 10 | 4.51 | .307 | 1.31 | 8.8 | 3.0 | 7.9 | 213.1 | 209 | 109 | 107 | 35 | 71 | 187 | 1 | 0 | 0 | 0 | 16 | 4 | 5 | 4.44 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 32 | 32 | 12 | 11 | 4.59 | .320 | 1.40 | 9.3 | 3.3 | 8.7 | 209.2 | 216 | 111 | 107 | 34 | 77 | 202 | 1 | 0 | 0 | 0 | 16 | 3 | 3 | 4.33 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 29 | 19 | 13 | 7 | 4.63 | .296 | 1.23 | 8.9 | 2.2 | 6.3 | 165.1 | 163 | 86 | 85 | 20 | 41 | 115 | 1 | 0 | 0 | 1 | 10 | 5 | 1 | 4.02 |
| CL | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 65 | 0 | 5 | 4 | 2.09 | .253 | 0.99 | 5.5 | 3.4 | 9.9 | 69.0 | 42 | 17 | 16 | 7 | 26 | 76 | 0 | 36 | 1 | 0 | 0 | 2 | 1 | 3.33 |
| SU | Marmol, C.Marmol, Carlos $$ >> | 26 | 2008 | R | 86 | 64 | 0 | 3 | 0 | 2.58 | .236 | 0.91 | 5.1 | 3.2 | 8.3 | 76.2 | 43 | 23 | 22 | 6 | 27 | 70 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 3.29 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 46 | 0 | 5 | 1 | 3.49 | .286 | 1.16 | 7.7 | 2.8 | 8.1 | 49.0 | 42 | 19 | 19 | 9 | 15 | 44 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.63 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 26 | 0 | 4 | 1 | 4.24 | .346 | 1.47 | 6.4 | 6.9 | 7.4 | 17.0 | 12 | 8 | 8 | 1 | 13 | 14 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.76 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 55 | 0 | 2 | 1 | 4.30 | .285 | 1.19 | 8.5 | 2.3 | 9.5 | 58.2 | 55 | 28 | 28 | 14 | 15 | 61 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.81 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 20 | 0 | 1 | 2 | 5.48 | .319 | 1.41 | 10.3 | 2.6 | 8.6 | 21.1 | 24 | 13 | 13 | 3 | 6 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.81 |
| SP | Garcia, F.Garcia, Freddy # >> | 25 | 2001 | R | 61 | 26 | 13 | 4 | 8 | 6.24 | .349 | 1.58 | 10.1 | 4.2 | 6.0 | 127.0 | 142 | 88 | 88 | 18 | 59 | 85 | 1 | 0 | 0 | 0 | 5 | 3 | 4 | 4.97 |