| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 2 | 2 | 1 | 1 | 8.38 | .370 | 1.76 | 11.0 | 6.0 | 10.0 | 9.2 | 11 | 9 | 9 | 6 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.44 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 2 | 2 | 0 | 1 | 19.06 | .514 | 3.00 | 19.8 | 10.8 | 10.8 | 5.2 | 11 | 13 | 12 | 3 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 12.60 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 2 | 2 | 0 | 0 | 8.64 | .444 | 2.28 | 18.0 | 3.4 | 11.3 | 8.1 | 16 | 8 | 8 | 1 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.63 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 2 | 2 | 0 | 0 | 7.36 | .353 | 1.64 | 10.6 | 4.1 | 6.5 | 11.0 | 13 | 9 | 9 | 4 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.64 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 6 | 0 | 0 | 2 | 5.14 | .276 | 1.14 | 6.4 | 3.9 | 5.1 | 7.0 | 5 | 4 | 4 | 1 | 3 | 4 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 6 | 0 | 0 | 0 | 3.68 | .290 | 1.23 | 7.7 | 3.9 | 5.1 | 7.1 | 6 | 3 | 3 | 1 | 3 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 5 | 0 | 0 | 0 | 3.60 | .348 | 1.60 | 10.8 | 3.6 | 12.6 | 5.0 | 6 | 2 | 2 | 0 | 2 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1.40 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 6 | 0 | 1 | 0 | 0.00 | .344 | 1.29 | 6.4 | 5.1 | 7.7 | 7.0 | 5 | 0 | 0 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.86 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 4 | 0 | 0 | 0 | 0.00 | .316 | 1.38 | 4.5 | 9.0 | 11.3 | 4.1 | 2 | 0 | 0 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 6 | 0 | 1 | 0 | 1.50 | .250 | 1.00 | 6.0 | 3.0 | 7.5 | 6.0 | 4 | 1 | 1 | 0 | 2 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.33 |