| SP | Johnson, R.Johnson, Randy # >> | 38 | 2001 | L | 97 | 37 | 37 | 14 | 12 | 4.10 | .304 | 1.27 | 8.7 | 2.8 | 10.8 | 254.2 | 246 | 116 | 116 | 33 | 78 | 305 | 4 | 0 | 0 | 3 | 19 | 10 | 7 | 3.33 |
| SP | Duchscherer, J.Duchscherer, Justin # >> | 31 | 2008 | R | 84 | 34 | 34 | 14 | 9 | 4.29 | .301 | 1.27 | 9.6 | 1.9 | 6.2 | 224.1 | 239 | 109 | 107 | 30 | 47 | 155 | 1 | 0 | 0 | 0 | 16 | 4 | 5 | 4.04 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 35 | 35 | 13 | 14 | 4.81 | .314 | 1.36 | 9.0 | 3.3 | 8.9 | 224.2 | 225 | 122 | 120 | 37 | 81 | 221 | 2 | 0 | 0 | 0 | 18 | 3 | 5 | 4.30 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 32 | 32 | 13 | 13 | 4.25 | .313 | 1.31 | 7.9 | 3.9 | 9.4 | 195.0 | 172 | 98 | 92 | 23 | 84 | 204 | 2 | 0 | 0 | 2 | 19 | 10 | 5 | 3.89 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 111 | 0 | 5 | 2 | 2.96 | .296 | 1.23 | 8.0 | 3.2 | 9.4 | 112.2 | 99 | 38 | 37 | 14 | 40 | 117 | 0 | 10 | 8 | 0 | 0 | 3 | 2 | 3.69 |
| RP | Gonzalez, M.Gonzalez, Mike † >> | 26 | 2004 | L | 74 | 75 | 0 | 9 | 2 | 3.42 | .283 | 1.13 | 7.4 | 2.8 | 9.0 | 68.1 | 56 | 26 | 26 | 9 | 21 | 68 | 0 | 9 | 2 | 0 | 0 | 4 | 3 | 3.82 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 76 | 0 | 5 | 10 | 4.42 | .282 | 1.16 | 7.1 | 3.3 | 7.7 | 57.0 | 45 | 31 | 28 | 4 | 21 | 49 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 3.35 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 51 | 0 | 3 | 3 | 5.23 | .338 | 1.44 | 9.6 | 3.3 | 8.2 | 43.0 | 46 | 25 | 25 | 7 | 16 | 39 | 0 | 5 | 1 | 0 | 0 | 4 | 3 | 4.70 |