| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 6 | 18 | 6.06 | .364 | 1.70 | 10.7 | 4.6 | 8.5 | 150.0 | 179 | 104 | 101 | 23 | 76 | 142 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 4.68 |
| SP | Kluber, C.Kluber, Corey † # >> | 31 | 2017 | R | 89 | 27 | 27 | 13 | 8 | 4.33 | .296 | 1.25 | 8.4 | 2.8 | 9.2 | 183.0 | 171 | 91 | 88 | 23 | 57 | 187 | 5 | 0 | 0 | 1 | 13 | 3 | 1 | 3.57 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 27 | 27 | 11 | 9 | 4.02 | .314 | 1.36 | 8.0 | 4.2 | 4.4 | 170.1 | 152 | 82 | 76 | 19 | 79 | 84 | 1 | 0 | 0 | 0 | 14 | 3 | 3 | 4.91 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 27 | 27 | 7 | 13 | 6.74 | .359 | 1.66 | 11.1 | 3.8 | 5.0 | 155.0 | 192 | 117 | 116 | 22 | 65 | 86 | 2 | 0 | 0 | 1 | 7 | 3 | 6 | 5.05 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 71 | 0 | 7 | 2 | 1.76 | .253 | 0.99 | 6.4 | 2.5 | 8.1 | 107.1 | 76 | 24 | 21 | 7 | 30 | 96 | 0 | 6 | 5 | 0 | 0 | 3 | 1 | 2.98 |
| RP | Williams, D.Williams, Devin # >> | 28 | 2023 | R | 72 | 63 | 0 | 5 | 4 | 5.64 | .332 | 1.48 | 6.2 | 7.1 | 8.0 | 75.0 | 52 | 48 | 47 | 10 | 59 | 67 | 0 | 9 | 2 | 0 | 0 | 1 | 2 | 5.35 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 49 | 0 | 4 | 3 | 3.68 | .310 | 1.34 | 9.1 | 3.0 | 6.9 | 63.2 | 64 | 26 | 26 | 11 | 21 | 48 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 4.79 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 1 | 0 | 0 | 0 | 0.00 | .333 | 0.00 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 20 | 0 | 1 | 0 | 3.34 | .300 | 1.29 | 9.0 | 2.6 | 7.2 | 35.0 | 35 | 13 | 13 | 2 | 10 | 28 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 3.00 |