| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 28 | 28 | 11 | 7 | 3.61 | .290 | 1.18 | 7.7 | 2.9 | 8.1 | 217.0 | 186 | 92 | 87 | 30 | 71 | 195 | 6 | 0 | 0 | 1 | 18 | 9 | 7 | 4.11 |
| SP | Scott, M.Scott, Mike # >> | 31 | 1986 | R | 87 | 27 | 27 | 11 | 10 | 4.66 | .310 | 1.32 | 8.6 | 3.3 | 7.1 | 202.2 | 193 | 109 | 105 | 22 | 74 | 159 | 8 | 0 | 0 | 0 | 10 | 6 | 5 | 4.03 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 27 | 27 | 9 | 13 | 5.32 | .342 | 1.55 | 11.0 | 3.0 | 7.0 | 167.1 | 204 | 108 | 99 | 24 | 55 | 130 | 1 | 0 | 0 | 0 | 12 | 2 | 15 | 4.34 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 25 | 25 | 6 | 6 | 4.83 | .311 | 1.33 | 8.4 | 3.6 | 3.9 | 154.2 | 144 | 92 | 83 | 24 | 61 | 67 | 0 | 0 | 0 | 0 | 12 | 4 | 1 | 5.42 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 72 | 0 | 8 | 7 | 4.08 | .307 | 1.32 | 7.7 | 4.2 | 8.7 | 90.1 | 77 | 44 | 41 | 8 | 42 | 87 | 0 | 8 | 6 | 0 | 0 | 1 | 3 | 3.66 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 61 | 0 | 5 | 3 | 3.72 | .317 | 1.38 | 7.6 | 4.9 | 7.0 | 72.2 | 61 | 32 | 30 | 8 | 39 | 56 | 0 | 10 | 3 | 0 | 0 | 1 | 1 | 4.56 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 42 | 0 | 3 | 6 | 4.53 | .311 | 1.34 | 8.1 | 4.1 | 7.9 | 51.2 | 46 | 30 | 26 | 8 | 23 | 45 | 0 | 3 | 3 | 0 | 0 | 1 | 3 | 4.69 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 36 | 0 | 0 | 5 | 5.35 | .373 | 1.76 | 9.7 | 6.1 | 6.8 | 37.0 | 40 | 23 | 22 | 5 | 25 | 28 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 5.35 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 49 | 3 | 0 | 1 | 0 | 8.10 | .375 | 1.80 | 18.0 | 0.0 | 9.0 | 3.1 | 6 | 3 | 3 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 18 | 0 | 0 | 2 | 5.61 | .336 | 1.52 | 8.6 | 5.4 | 4.3 | 25.2 | 24 | 16 | 16 | 4 | 15 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.92 |