| SP | deGrom, J.deGrom, Jacob † # >> | 33 | 2021 | R | 100 | 28 | 28 | 10 | 9 | 3.59 | .278 | 1.12 | 7.5 | 2.6 | 9.8 | 188.0 | 157 | 81 | 75 | 22 | 54 | 205 | 1 | 0 | 0 | 0 | 18 | 6 | 0 | 3.30 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 27 | 27 | 10 | 8 | 3.98 | .329 | 1.45 | 9.5 | 3.6 | 4.7 | 201.1 | 212 | 93 | 89 | 21 | 80 | 105 | 2 | 0 | 0 | 0 | 16 | 4 | 6 | 4.57 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 26 | 26 | 10 | 10 | 6.61 | .354 | 1.63 | 11.4 | 3.2 | 4.8 | 147.0 | 187 | 114 | 108 | 23 | 53 | 78 | 1 | 0 | 0 | 0 | 11 | 2 | 5 | 5.10 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 73 | 0 | 5 | 6 | 3.32 | .269 | 1.11 | 7.7 | 2.3 | 8.7 | 100.1 | 86 | 39 | 37 | 11 | 25 | 97 | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 3.24 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 76 | 0 | 6 | 4 | 5.32 | .328 | 1.47 | 11.1 | 2.0 | 8.6 | 88.0 | 109 | 55 | 52 | 18 | 20 | 84 | 0 | 9 | 8 | 0 | 0 | 0 | 2 | 4.43 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 56 | 0 | 1 | 3 | 4.08 | .275 | 1.09 | 6.2 | 3.7 | 7.5 | 64.0 | 44 | 30 | 29 | 8 | 26 | 53 | 0 | 8 | 0 | 0 | 0 | 3 | 6 | 4.33 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 3 | 0 | 0 | 0 | 3.86 | .333 | 1.50 | 15.8 | 0.0 | 9.0 | 4.2 | 7 | 2 | 2 | 2 | 0 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.50 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 21 | 0 | 6 | 4 | 4.66 | .326 | 1.42 | 8.3 | 4.7 | 6.6 | 38.2 | 35 | 20 | 20 | 8 | 20 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.92 |