| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 11 | 11 | 3 | 4 | 3.52 | .246 | 0.95 | 6.2 | 2.4 | 8.4 | 71.2 | 49 | 30 | 28 | 6 | 19 | 66 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 3.13 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 11 | 11 | 3 | 4 | 3.88 | .298 | 1.28 | 8.4 | 3.1 | 5.4 | 58.0 | 54 | 25 | 25 | 3 | 20 | 35 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.50 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 10 | 10 | 3 | 4 | 4.75 | .335 | 1.47 | 10.0 | 3.2 | 4.4 | 53.0 | 59 | 29 | 28 | 7 | 19 | 26 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.92 |
| SU | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 27 | 0 | 1 | 1 | 4.91 | .302 | 1.26 | 9.0 | 2.5 | 8.7 | 29.1 | 29 | 16 | 16 | 5 | 8 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.24 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 28 | 0 | 1 | 0 | 4.91 | .333 | 1.50 | 10.6 | 3.1 | 8.4 | 29.1 | 34 | 16 | 16 | 3 | 10 | 27 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 3.52 |
| RP | Orosco, J.Orosco, Jesse >> | 26 | 1983 | L | 25 | 30 | 0 | 1 | 1 | 6.91 | .317 | 1.39 | 9.0 | 3.7 | 7.0 | 27.1 | 27 | 21 | 21 | 9 | 11 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |