| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 38 | 38 | 12 | 15 | 4.22 | .294 | 1.22 | 8.1 | 2.9 | 8.8 | 219.2 | 198 | 108 | 103 | 24 | 70 | 215 | 1 | 0 | 0 | 1 | 22 | 6 | 0 | 3.50 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 35 | 35 | 10 | 9 | 4.42 | .302 | 1.28 | 8.3 | 3.2 | 4.5 | 175.0 | 161 | 89 | 86 | 20 | 63 | 87 | 0 | 0 | 0 | 0 | 12 | 3 | 3 | 4.62 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 34 | 34 | 11 | 15 | 5.58 | .338 | 1.51 | 10.7 | 3.0 | 5.3 | 179.0 | 212 | 119 | 111 | 30 | 59 | 105 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 5.04 |
| SU | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 103 | 0 | 8 | 3 | 3.89 | .300 | 1.26 | 8.4 | 2.9 | 8.3 | 113.1 | 106 | 55 | 49 | 19 | 37 | 104 | 0 | 4 | 5 | 0 | 0 | 3 | 2 | 4.41 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 99 | 0 | 5 | 8 | 3.23 | .272 | 1.10 | 5.4 | 4.5 | 10.4 | 119.2 | 72 | 43 | 43 | 7 | 60 | 138 | 0 | 42 | 7 | 0 | 0 | 2 | 0 | 3.01 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 94 | 0 | 4 | 0 | 3.98 | .295 | 1.26 | 8.2 | 3.2 | 8.2 | 110.2 | 100 | 51 | 49 | 12 | 39 | 100 | 0 | 2 | 3 | 0 | 0 | 0 | 7 | 3.66 |
| RP | Orosco, J.Orosco, Jesse >> | 26 | 1983 | L | 25 | 104 | 0 | 4 | 5 | 6.23 | .329 | 1.46 | 9.2 | 3.9 | 4.8 | 117.0 | 120 | 81 | 81 | 21 | 51 | 62 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 5.61 |