| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 28 | 28 | 16 | 7 | 2.95 | .264 | 1.06 | 7.3 | 2.3 | 8.0 | 216.2 | 174 | 74 | 71 | 19 | 55 | 192 | 12 | 0 | 0 | 2 | 20 | 4 | 4 | 3.19 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 28 | 28 | 14 | 8 | 2.96 | .241 | 0.95 | 6.4 | 2.1 | 9.3 | 197.1 | 141 | 66 | 65 | 17 | 47 | 204 | 2 | 0 | 0 | 1 | 21 | 0 | 2 | 2.77 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 27 | 27 | 12 | 10 | 3.81 | .281 | 1.16 | 8.0 | 2.5 | 7.6 | 201.0 | 178 | 88 | 85 | 23 | 55 | 170 | 7 | 0 | 0 | 0 | 16 | 3 | 3 | 3.66 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 27 | 27 | 14 | 5 | 3.86 | .288 | 1.20 | 6.6 | 4.2 | 8.9 | 165.2 | 121 | 72 | 71 | 13 | 77 | 163 | 1 | 0 | 0 | 0 | 16 | 3 | 3 | 3.50 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 25 | 24 | 10 | 8 | 5.03 | .325 | 1.43 | 9.8 | 3.0 | 4.4 | 154.0 | 168 | 87 | 86 | 14 | 52 | 76 | 7 | 0 | 0 | 3 | 10 | 2 | 9 | 4.25 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 67 | 0 | 5 | 6 | 3.29 | .273 | 1.12 | 7.7 | 2.5 | 9.1 | 87.2 | 74 | 35 | 32 | 12 | 24 | 88 | 0 | 13 | 2 | 0 | 0 | 1 | 1 | 3.63 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 59 | 0 | 2 | 6 | 2.90 | .241 | 0.94 | 5.7 | 2.8 | 8.4 | 71.1 | 45 | 24 | 23 | 8 | 22 | 66 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 3.58 |
| RP | Hader, J.Hader, Josh # >> | 24 | 2018 | L | 93 | 32 | 0 | 2 | 2 | 6.86 | .337 | 1.47 | 9.0 | 4.4 | 9.9 | 39.1 | 39 | 32 | 30 | 7 | 19 | 43 | 0 | 7 | 1 | 0 | 0 | 2 | 0 | 4.74 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 21 | 0 | 3 | 1 | 0.68 | .231 | 0.90 | 5.2 | 3.1 | 9.7 | 26.2 | 15 | 2 | 2 | 1 | 9 | 28 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.38 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 17 | 0 | 0 | 1 | 4.26 | .337 | 1.53 | 9.5 | 4.3 | 8.5 | 19.0 | 20 | 9 | 9 | 2 | 9 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.89 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 25 | 0 | 2 | 0 | 1.67 | .206 | 0.74 | 5.0 | 1.7 | 10.7 | 27.0 | 15 | 5 | 5 | 1 | 5 | 32 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 1.78 |