| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 11 | 11 | 6 | 4 | 5.68 | .329 | 1.43 | 10.1 | 2.9 | 9.8 | 82.1 | 92 | 58 | 52 | 13 | 26 | 89 | 2 | 0 | 0 | 0 | 3 | 3 | 1 | 3.95 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 11 | 11 | 4 | 5 | 3.23 | .301 | 1.28 | 8.5 | 3.1 | 8.5 | 83.2 | 78 | 34 | 30 | 5 | 29 | 78 | 3 | 0 | 0 | 1 | 7 | 1 | 1 | 2.99 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 71 | 8 | 8 | 3 | 5 | 6.54 | .338 | 1.53 | 10.0 | 3.8 | 8.5 | 52.1 | 58 | 42 | 38 | 14 | 22 | 49 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 5.88 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 5 | 5 | 2 | 2 | 4.63 | .352 | 1.57 | 10.8 | 3.3 | 3.6 | 35.0 | 42 | 18 | 18 | 4 | 13 | 14 | 2 | 0 | 0 | 0 | 3 | 2 | 0 | 4.97 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 25 | 0 | 2 | 0 | 1.35 | .231 | 0.86 | 3.5 | 4.5 | 9.0 | 26.2 | 10 | 4 | 4 | 0 | 13 | 26 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.62 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 14 | 0 | 1 | 0 | 8.03 | .464 | 2.51 | 16.5 | 6.8 | 6.0 | 12.1 | 22 | 11 | 11 | 2 | 9 | 8 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 6.33 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 5 | 0 | 0 | 0 | 9.53 | .370 | 1.76 | 12.6 | 5.4 | 14.4 | 5.2 | 7 | 6 | 6 | 0 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.60 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 3 | 0 | 0 | 0 | 0.00 | .125 | 0.43 | 0.0 | 4.5 | 9.0 | 4.2 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 7 | 7 | 1 | 5 | 7.59 | .373 | 1.76 | 12.4 | 3.6 | 9.2 | 40.1 | 55 | 37 | 34 | 9 | 16 | 41 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 5.15 |