| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 36 | 36 | 17 | 15 | 4.02 | .295 | 1.23 | 8.3 | 2.8 | 8.9 | 275.2 | 253 | 131 | 123 | 29 | 87 | 273 | 11 | 0 | 0 | 2 | 20 | 6 | 3 | 3.40 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 35 | 35 | 11 | 16 | 5.09 | .337 | 1.50 | 9.4 | 4.0 | 9.0 | 214.0 | 224 | 125 | 121 | 28 | 96 | 214 | 1 | 0 | 0 | 1 | 17 | 7 | 2 | 4.14 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 34 | 34 | 14 | 13 | 4.58 | .321 | 1.40 | 9.7 | 2.9 | 7.5 | 236.0 | 255 | 129 | 120 | 34 | 75 | 197 | 4 | 0 | 0 | 1 | 16 | 5 | 4 | 4.22 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 71 | 21 | 21 | 11 | 8 | 4.56 | .309 | 1.32 | 9.1 | 2.8 | 7.9 | 152.0 | 154 | 84 | 77 | 25 | 47 | 134 | 4 | 0 | 0 | 0 | 9 | 3 | 1 | 4.36 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 26 | 26 | 8 | 12 | 4.91 | .336 | 1.49 | 9.8 | 3.7 | 5.2 | 183.1 | 199 | 102 | 100 | 29 | 75 | 106 | 7 | 0 | 0 | 0 | 11 | 4 | 6 | 5.20 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 97 | 90 | 0 | 5 | 2 | 2.58 | .282 | 1.16 | 6.1 | 4.4 | 9.3 | 118.2 | 80 | 41 | 34 | 7 | 58 | 122 | 0 | 10 | 1 | 0 | 0 | 2 | 2 | 3.23 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 74 | 0 | 5 | 3 | 3.29 | .290 | 1.19 | 6.5 | 4.3 | 9.8 | 76.2 | 55 | 33 | 28 | 8 | 36 | 83 | 0 | 11 | 5 | 0 | 0 | 3 | 0 | 3.72 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 46 | 0 | 4 | 0 | 3.25 | .298 | 1.25 | 8.1 | 3.3 | 8.7 | 52.2 | 47 | 21 | 19 | 5 | 19 | 50 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 3.48 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 22 | 0 | 2 | 0 | 5.04 | .299 | 1.28 | 8.3 | 3.2 | 8.6 | 25.0 | 23 | 14 | 14 | 1 | 9 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.68 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 20 | 0 | 1 | 0 | 1.78 | .248 | 0.95 | 5.0 | 3.6 | 9.7 | 25.1 | 14 | 5 | 5 | 2 | 10 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 5 | 3.20 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 18 | 17 | 4 | 10 | 5.10 | .319 | 1.37 | 9.6 | 2.8 | 9.0 | 113.0 | 120 | 71 | 64 | 18 | 35 | 113 | 1 | 0 | 0 | 0 | 7 | 4 | 2 | 4.11 |