| SP | Kershaw, C.Kershaw, Clayton >> | 34 | 2022 | L | 94 | 7 | 7 | 3 | 2 | 2.13 | .278 | 1.11 | 6.9 | 3.2 | 10.5 | 42.1 | 32 | 10 | 10 | 1 | 15 | 49 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 2.19 |
| SP | Anderson, T.Anderson, Tyler # >> | 32 | 2022 | L | 82 | 7 | 7 | 3 | 2 | 5.40 | .339 | 1.49 | 9.9 | 3.7 | 6.8 | 41.2 | 45 | 25 | 25 | 5 | 17 | 31 | 1 | 0 | 0 | 0 | 4 | 2 | 5 | 4.46 |
| SP | Rasmussen, D.Rasmussen, Drew >> | 26 | 2022 | R | 77 | 7 | 7 | 2 | 2 | 5.09 | .321 | 1.33 | 10.0 | 2.1 | 8.2 | 35.1 | 39 | 21 | 20 | 4 | 8 | 32 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 3.60 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 92 | 7 | 7 | 5 | 0 | 3.47 | .317 | 1.37 | 11.2 | 1.4 | 9.8 | 46.2 | 57 | 19 | 18 | 3 | 7 | 50 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 2.20 |
| RP | Phillips, E.Phillips, Evan >> | 27 | 2022 | R | 99 | 19 | 0 | 0 | 1 | 2.96 | .317 | 1.35 | 9.0 | 3.3 | 13.7 | 27.1 | 27 | 9 | 9 | 3 | 10 | 41 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.63 |
| RP | Murfee, P.Murfee, Penn >> | 28 | 2022 | R | 89 | 9 | 0 | 3 | 1 | 3.09 | .205 | 0.69 | 2.5 | 4.1 | 7.4 | 11.2 | 3 | 4 | 4 | 1 | 5 | 9 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.18 |
| RP | Herget, J.Herget, Jimmy >> | 28 | 2022 | R | 87 | 6 | 0 | 0 | 0 | 3.86 | .382 | 1.86 | 16.7 | 0.0 | 5.1 | 7.0 | 13 | 3 | 3 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.57 |
| RP | Martin, C.Martin, Chris >> | 36 | 2022 | R | 75 | 6 | 0 | 1 | 0 | 4.05 | .259 | 1.05 | 7.5 | 3.0 | 9.0 | 6.2 | 5 | 3 | 3 | 0 | 2 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 65 | 1 | 0 | 0 | 0 | 9.00 | .500 | 2.00 | 9.0 | 9.0 | 9.0 | 1.0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 7.00 |