| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 97 | 7 | 7 | 4 | 0 | 2.59 | .291 | 1.19 | 8.1 | 2.8 | 11.1 | 48.2 | 43 | 14 | 14 | 4 | 15 | 59 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 2.69 |
| SP | Luzardo, J.Luzardo, Jesus >> | 24 | 2022 | L | 88 | 7 | 7 | 0 | 2 | 4.50 | .338 | 1.53 | 9.3 | 4.5 | 10.7 | 32.0 | 33 | 16 | 16 | 4 | 16 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.75 |
| SP | Castillo, L.Castillo, Luis >> | 29 | 2022 | R | 83 | 7 | 7 | 3 | 2 | 4.30 | .298 | 1.23 | 9.0 | 2.0 | 9.2 | 44.0 | 44 | 21 | 21 | 7 | 10 | 45 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 3.84 |
| CL | Romano, J.Romano, Jordan >> | 29 | 2022 | R | 83 | 17 | 0 | 2 | 2 | 1.96 | .289 | 1.17 | 6.7 | 3.9 | 9.4 | 23.0 | 17 | 5 | 5 | 0 | 10 | 24 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 2.35 |
| RP | Raley, B.Raley, Brooks >> | 34 | 2022 | L | 88 | 21 | 0 | 3 | 2 | 4.00 | .331 | 1.44 | 10.0 | 3.0 | 13.3 | 27.0 | 30 | 12 | 12 | 3 | 9 | 40 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.59 |
| RP | Lopez, R.Lopez, Reynaldo >> | 28 | 2022 | R | 78 | 21 | 0 | 2 | 0 | 3.86 | .307 | 1.29 | 8.6 | 3.1 | 7.0 | 23.1 | 22 | 10 | 10 | 2 | 8 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.74 |
| RP | Alvarado, J.Alvarado, Jose >> | 27 | 2022 | L | 66 | 20 | 0 | 1 | 3 | 5.03 | .372 | 1.73 | 10.9 | 5.2 | 13.3 | 19.2 | 23 | 11 | 11 | 3 | 11 | 28 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 4.00 |