| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 97 | 23 | 23 | 8 | 6 | 3.48 | .313 | 1.29 | 8.8 | 2.8 | 9.4 | 155.1 | 152 | 64 | 60 | 17 | 49 | 162 | 0 | 0 | 0 | 0 | 16 | 11 | 5 | 3.50 |
| SP | Wheeler, Z.Wheeler, Zack >> | 32 | 2022 | R | 84 | 22 | 22 | 8 | 11 | 5.61 | .327 | 1.43 | 10.2 | 2.7 | 9.1 | 131.2 | 148 | 82 | 82 | 17 | 40 | 132 | 0 | 0 | 0 | 0 | 9 | 4 | 4 | 3.68 |
| SP | Bieber, S.Bieber, Shane >> | 27 | 2022 | R | 78 | 22 | 22 | 10 | 9 | 4.39 | .317 | 1.32 | 9.2 | 2.7 | 7.7 | 151.2 | 155 | 77 | 74 | 16 | 45 | 130 | 1 | 0 | 0 | 1 | 11 | 11 | 4 | 3.77 |
| SP | Bassitt, C.Bassitt, Chris >> | 33 | 2022 | R | 67 | 21 | 21 | 8 | 8 | 4.98 | .346 | 1.52 | 10.1 | 3.7 | 7.9 | 128.1 | 143 | 72 | 71 | 18 | 52 | 112 | 1 | 0 | 0 | 1 | 9 | 9 | 4 | 4.51 |
| RP | Iglesias, R.Iglesias, Raisel # >> | 32 | 2022 | R | 87 | 54 | 0 | 2 | 3 | 2.92 | .276 | 1.11 | 7.4 | 2.7 | 10.3 | 71.0 | 58 | 23 | 23 | 4 | 21 | 81 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 2.42 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 30 | 2022 | R | 82 | 48 | 0 | 4 | 4 | 4.61 | .308 | 1.32 | 8.7 | 3.3 | 10.8 | 54.2 | 52 | 28 | 28 | 9 | 20 | 65 | 0 | 8 | 3 | 0 | 0 | 1 | 1 | 3.93 |
| SP | Kopech, M.Kopech, Michael >> | 26 | 2022 | R | 72 | 2 | 0 | 0 | 0 | 10.80 | .444 | 2.40 | 27.0 | 9.0 | 18.0 | 1.2 | 3 | 2 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Romano, J.Romano, Jordan >> | 29 | 2022 | R | 83 | 17 | 0 | 0 | 1 | 8.10 | .420 | 2.10 | 14.5 | 4.8 | 13.2 | 13.1 | 21 | 12 | 12 | 4 | 7 | 19 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.92 |
| RP | Jansen, K.Jansen, Kenley >> | 34 | 2022 | R | 81 | 16 | 0 | 1 | 0 | 4.05 | .341 | 1.45 | 8.1 | 5.0 | 9.5 | 20.0 | 18 | 9 | 9 | 1 | 11 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.50 |