| SP | Verlander, J.Verlander, Justin $$ >> | 39 | 2022 | R | 100 | 23 | 23 | 10 | 6 | 3.70 | .293 | 1.20 | 9.0 | 1.8 | 10.1 | 153.1 | 153 | 64 | 63 | 12 | 31 | 171 | 0 | 0 | 0 | 0 | 15 | 7 | 1 | 2.53 |
| SP | Ohtani, S.Ohtani, Shohei # >> | 27 | 2022 | R | 91 | 22 | 22 | 11 | 7 | 3.56 | .290 | 1.17 | 8.1 | 2.4 | 10.4 | 136.1 | 123 | 54 | 54 | 12 | 36 | 157 | 2 | 0 | 0 | 0 | 13 | 8 | 6 | 2.81 |
| SP | Woodruff, B.Woodruff, Brandon >> | 29 | 2022 | R | 85 | 22 | 22 | 10 | 6 | 3.62 | .322 | 1.38 | 9.6 | 2.9 | 8.4 | 129.1 | 137 | 61 | 52 | 18 | 41 | 121 | 0 | 0 | 0 | 0 | 9 | 6 | 2 | 4.03 |
| SP | Valdez, F.Valdez, Framber >> | 28 | 2022 | L | 72 | 22 | 22 | 9 | 8 | 4.09 | .321 | 1.38 | 9.4 | 3.0 | 7.0 | 143.0 | 150 | 69 | 65 | 17 | 47 | 111 | 1 | 0 | 0 | 0 | 10 | 6 | 4 | 4.10 |
| SP | Skubal, T.Skubal, Tarik >> | 25 | 2022 | L | 65 | 22 | 21 | 8 | 5 | 4.88 | .324 | 1.42 | 10.9 | 1.9 | 8.4 | 118.0 | 143 | 71 | 64 | 25 | 25 | 110 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 4.58 |
| RP | McHugh, C.McHugh, Collin >> | 35 | 2022 | R | 85 | 62 | 0 | 4 | 4 | 3.65 | .301 | 1.25 | 8.1 | 3.2 | 10.1 | 79.0 | 71 | 38 | 32 | 13 | 28 | 89 | 0 | 0 | 2 | 0 | 0 | 3 | 6 | 4.06 |
| RP | Martin, C.Martin, Chris >> | 36 | 2022 | R | 75 | 56 | 0 | 3 | 2 | 2.51 | .254 | 1.01 | 7.9 | 1.3 | 8.7 | 64.2 | 56 | 20 | 18 | 9 | 9 | 62 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.36 |
| RP | Murfee, P.Murfee, Penn >> | 28 | 2022 | R | 89 | 35 | 0 | 4 | 1 | 5.45 | .303 | 1.30 | 10.1 | 1.6 | 13.1 | 33.0 | 37 | 21 | 20 | 4 | 6 | 48 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.21 |
| RP | Bednar, D.Bednar, David >> | 27 | 2022 | R | 67 | 32 | 0 | 2 | 0 | 4.32 | .338 | 1.53 | 9.8 | 4.1 | 9.3 | 33.1 | 36 | 16 | 16 | 7 | 15 | 34 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.06 |
| SU | Hentges, S.Hentges, Sam >> | 25 | 2022 | L | 92 | 37 | 0 | 1 | 3 | 4.62 | .331 | 1.44 | 10.6 | 2.3 | 10.6 | 39.0 | 46 | 21 | 20 | 5 | 10 | 46 | 0 | 2 | 3 | 0 | 0 | 2 | 1 | 3.23 |
| CL | Sewald, P.Sewald, Paul † >> | 32 | 2022 | R | 98 | 46 | 0 | 3 | 3 | 2.11 | .288 | 1.19 | 5.7 | 5.0 | 9.4 | 47.0 | 30 | 13 | 11 | 3 | 26 | 49 | 0 | 27 | 1 | 0 | 0 | 1 | 0 | 3.47 |