| SP | Clemens, R.Clemens, Roger >> | 27 | 1989 | R | 50 | 12 | 12 | 6 | 4 | 5.89 | .339 | 1.53 | 8.6 | 5.2 | 6.3 | 73.1 | 70 | 48 | 48 | 9 | 42 | 51 | 1 | 0 | 0 | 0 | 3 | 1 | 3 | 4.97 |
| SP | Martinez, P.Martinez, Pedro >> | 33 | 2004 | R | 51 | 12 | 12 | 3 | 6 | 6.24 | .364 | 1.72 | 11.7 | 3.9 | 8.4 | 57.2 | 74 | 45 | 40 | 9 | 25 | 53 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.51 |
| SP | Wakefield, T.Wakefield, Tim >> | 37 | 2003 | R | 32 | 11 | 11 | 3 | 7 | 7.35 | .388 | 1.88 | 13.0 | 3.9 | 4.4 | 49.0 | 71 | 45 | 40 | 5 | 21 | 24 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.69 |
| RP | Garces, R.Garces, Rich >> | 30 | 2001 | R | 31 | 29 | 0 | 0 | 0 | 3.32 | .274 | 1.13 | 5.4 | 4.7 | 5.4 | 38.0 | 23 | 14 | 14 | 3 | 20 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.39 |
| RP | Eckersley, D.Eckersley, Dennis >> | 44 | 1998 | R | 8 | 22 | 0 | 0 | 0 | 2.45 | .280 | 1.13 | 8.6 | 1.8 | 4.7 | 25.2 | 24 | 8 | 7 | 2 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.72 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 30 | 2010 | R | 31 | 11 | 0 | 1 | 1 | 5.89 | .361 | 1.67 | 10.0 | 5.1 | 5.7 | 44.1 | 49 | 32 | 29 | 5 | 25 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.98 |
| RP | Uehara, K.Uehara, Koji >> | 40 | 2015 | R | 63 | 15 | 0 | 2 | 0 | 2.12 | .329 | 1.47 | 10.1 | 3.2 | 9.0 | 17.0 | 19 | 5 | 4 | 0 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.06 |
| RP | Timlin, M.Timlin, Mike >> | 38 | 2004 | R | 23 | 19 | 0 | 0 | 0 | 7.23 | .349 | 1.61 | 12.0 | 3.0 | 5.5 | 18.2 | 24 | 15 | 15 | 6 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.11 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 28 | 2008 | R | 45 | 24 | 0 | 0 | 2 | 6.04 | .380 | 1.84 | 12.3 | 4.5 | 8.2 | 22.1 | 30 | 15 | 15 | 2 | 11 | 20 | 0 | 12 | 2 | 0 | 0 | 0 | 1 | 3.86 |