| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 62 | 28 | 28 | 13 | 9 | 4.15 | .299 | 1.26 | 7.7 | 3.8 | 8.6 | 160.2 | 136 | 76 | 74 | 12 | 67 | 153 | 3 | 0 | 0 | 2 | 15 | 3 | 6 | 3.38 |
| SP | Darvish, Y.Darvish, Yu # >> | 35 | 2022 | R | 57 | 29 | 28 | 13 | 9 | 4.56 | .317 | 1.38 | 9.5 | 2.9 | 8.5 | 169.2 | 179 | 90 | 86 | 18 | 55 | 159 | 4 | 0 | 0 | 1 | 13 | 2 | 0 | 3.51 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 55 | 27 | 26 | 12 | 10 | 4.98 | .332 | 1.47 | 9.4 | 3.9 | 8.0 | 151.2 | 158 | 89 | 84 | 18 | 65 | 135 | 0 | 0 | 0 | 0 | 11 | 3 | 4 | 4.11 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 100 | 60 | 0 | 3 | 6 | 3.17 | .276 | 1.13 | 6.7 | 3.4 | 9.5 | 71.0 | 53 | 27 | 25 | 3 | 27 | 75 | 0 | 26 | 2 | 0 | 0 | 1 | 0 | 2.62 |
| SU | Street, H.Street, Huston >> | 29 | 2012 | R | 99 | 69 | 0 | 3 | 4 | 4.96 | .326 | 1.40 | 7.7 | 4.8 | 8.9 | 78.0 | 67 | 44 | 43 | 9 | 42 | 77 | 0 | 3 | 4 | 0 | 0 | 4 | 4 | 4.29 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 93 | 71 | 0 | 2 | 2 | 3.64 | .277 | 1.14 | 7.0 | 3.3 | 9.0 | 81.2 | 63 | 36 | 33 | 13 | 30 | 81 | 0 | 2 | 4 | 0 | 0 | 1 | 4 | 4.23 |
| RP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 85 | 66 | 0 | 2 | 3 | 2.58 | .280 | 1.13 | 6.5 | 3.7 | 9.4 | 101.1 | 73 | 34 | 29 | 7 | 42 | 106 | 0 | 2 | 2 | 0 | 0 | 3 | 2 | 3.14 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 81 | 50 | 0 | 2 | 4 | 4.42 | .309 | 1.32 | 8.5 | 3.4 | 8.5 | 53.0 | 50 | 28 | 26 | 7 | 20 | 50 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.02 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 67 | 85 | 0 | 3 | 0 | 2.67 | .268 | 1.09 | 6.2 | 3.6 | 9.8 | 81.0 | 56 | 27 | 24 | 8 | 32 | 88 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.33 |