| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 23 | 23 | 7 | 8 | 4.18 | .291 | 1.21 | 8.1 | 2.9 | 10.7 | 144.1 | 129 | 67 | 67 | 18 | 46 | 171 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 3.27 |
| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 96 | 22 | 22 | 14 | 6 | 3.74 | .278 | 1.16 | 8.5 | 1.9 | 5.0 | 168.2 | 159 | 81 | 70 | 21 | 36 | 94 | 8 | 0 | 0 | 0 | 13 | 0 | 2 | 4.15 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 10 | 9 | 4.27 | .314 | 1.34 | 8.1 | 4.0 | 8.2 | 147.2 | 133 | 77 | 70 | 21 | 65 | 134 | 0 | 0 | 0 | 0 | 11 | 5 | 5 | 4.46 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 22 | 22 | 4 | 12 | 7.98 | .394 | 1.93 | 13.2 | 4.1 | 4.9 | 115.0 | 169 | 110 | 102 | 17 | 53 | 63 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 5.26 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 21 | 21 | 8 | 10 | 4.96 | .337 | 1.51 | 9.9 | 3.7 | 3.9 | 136.0 | 149 | 80 | 75 | 18 | 56 | 59 | 2 | 0 | 0 | 0 | 9 | 2 | 4 | 5.13 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 53 | 0 | 3 | 1 | 2.54 | .286 | 1.17 | 7.3 | 3.4 | 7.8 | 67.1 | 54 | 21 | 19 | 7 | 25 | 58 | 0 | 8 | 0 | 0 | 0 | 2 | 1 | 3.84 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 26 | 0 | 0 | 1 | 3.94 | .294 | 1.25 | 5.6 | 5.9 | 7.8 | 29.2 | 18 | 14 | 13 | 5 | 19 | 25 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.48 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 17 | 0 | 1 | 1 | 5.68 | .337 | 1.47 | 9.5 | 3.8 | 7.6 | 19.0 | 20 | 16 | 12 | 3 | 8 | 16 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.79 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 6 | 0 | 1 | 0 | 12.27 | .431 | 2.27 | 15.5 | 4.9 | 5.7 | 11.0 | 19 | 15 | 15 | 5 | 6 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 9.27 |