| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 26 | 26 | 10 | 9 | 4.08 | .306 | 1.32 | 8.0 | 3.9 | 8.6 | 176.1 | 156 | 83 | 80 | 17 | 76 | 168 | 2 | 0 | 0 | 1 | 15 | 1 | 4 | 3.66 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 25 | 25 | 8 | 11 | 4.00 | .296 | 1.25 | 9.2 | 2.1 | 5.7 | 186.2 | 190 | 86 | 83 | 17 | 44 | 118 | 8 | 0 | 0 | 0 | 13 | 1 | 2 | 3.65 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 57 | 0 | 5 | 4 | 5.74 | .346 | 1.59 | 12.1 | 2.3 | 7.5 | 64.1 | 86 | 42 | 41 | 10 | 16 | 53 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 45 | 0 | 4 | 4 | 4.69 | .327 | 1.42 | 11.4 | 1.3 | 6.0 | 48.0 | 61 | 27 | 25 | 6 | 7 | 32 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 3.85 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 25 | 0 | 2 | 2 | 1.35 | .252 | 0.98 | 6.2 | 2.8 | 6.9 | 26.2 | 18 | 4 | 4 | 1 | 8 | 20 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.00 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 16 | 0 | 1 | 0 | 3.54 | .274 | 1.13 | 6.3 | 4.1 | 7.2 | 20.1 | 14 | 8 | 8 | 2 | 9 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.05 |