| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 90 | 25 | 25 | 7 | 11 | 4.13 | .294 | 1.23 | 9.6 | 1.6 | 6.7 | 180.2 | 192 | 88 | 83 | 18 | 31 | 133 | 8 | 0 | 0 | 1 | 14 | 3 | 5 | 3.39 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 24 | 24 | 7 | 7 | 4.49 | .328 | 1.45 | 7.9 | 5.1 | 8.6 | 142.1 | 125 | 76 | 71 | 15 | 81 | 136 | 0 | 0 | 0 | 0 | 12 | 2 | 2 | 4.21 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 64 | 24 | 24 | 8 | 11 | 5.50 | .354 | 1.61 | 10.5 | 4.0 | 7.2 | 144.0 | 168 | 93 | 88 | 32 | 64 | 115 | 2 | 0 | 0 | 1 | 10 | 5 | 0 | 5.73 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 23 | 23 | 9 | 6 | 4.29 | .320 | 1.37 | 9.1 | 3.2 | 7.6 | 134.1 | 136 | 75 | 64 | 27 | 48 | 113 | 0 | 0 | 0 | 0 | 12 | 6 | 2 | 5.14 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 61 | 0 | 4 | 5 | 4.48 | .320 | 1.40 | 7.5 | 5.2 | 10.4 | 82.1 | 68 | 42 | 41 | 8 | 47 | 95 | 0 | 5 | 3 | 0 | 0 | 1 | 10 | 3.71 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 84 | 63 | 0 | 8 | 1 | 2.81 | .292 | 1.20 | 8.1 | 2.7 | 8.2 | 83.1 | 75 | 27 | 26 | 5 | 25 | 76 | 0 | 7 | 4 | 0 | 0 | 3 | 2 | 2.96 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 48 | 0 | 4 | 3 | 4.70 | .314 | 1.35 | 7.2 | 5.1 | 7.9 | 51.2 | 41 | 28 | 27 | 4 | 29 | 45 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.02 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 73 | 34 | 0 | 1 | 2 | 4.26 | .309 | 1.29 | 9.2 | 2.4 | 11.8 | 38.0 | 39 | 19 | 18 | 9 | 10 | 50 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.39 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 10 | 0 | 1 | 0 | 8.22 | .410 | 2.09 | 10.8 | 8.4 | 8.4 | 15.1 | 18 | 14 | 14 | 3 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.53 |