| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 25 | 25 | 8 | 10 | 4.56 | .298 | 1.24 | 8.4 | 2.8 | 9.4 | 169.2 | 157 | 89 | 86 | 21 | 53 | 177 | 1 | 0 | 0 | 0 | 13 | 6 | 1 | 3.57 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 25 | 25 | 8 | 12 | 5.94 | .341 | 1.53 | 9.9 | 3.9 | 9.2 | 145.1 | 160 | 98 | 96 | 28 | 63 | 149 | 0 | 0 | 0 | 0 | 11 | 3 | 4 | 4.82 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 24 | 24 | 6 | 11 | 4.66 | .329 | 1.45 | 8.9 | 4.2 | 9.1 | 143.0 | 141 | 75 | 74 | 22 | 66 | 144 | 0 | 0 | 0 | 0 | 9 | 3 | 10 | 4.43 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 24 | 24 | 12 | 5 | 3.11 | .302 | 1.27 | 8.2 | 3.2 | 6.6 | 133.0 | 121 | 49 | 46 | 13 | 48 | 97 | 0 | 0 | 0 | 0 | 9 | 4 | 1 | 3.98 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 84 | 26 | 24 | 6 | 11 | 4.98 | .333 | 1.47 | 9.6 | 3.8 | 7.9 | 144.2 | 153 | 80 | 80 | 21 | 60 | 127 | 0 | 0 | 0 | 0 | 10 | 4 | 4 | 4.47 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 67 | 0 | 1 | 5 | 3.61 | .298 | 1.24 | 6.5 | 4.7 | 9.6 | 99.2 | 72 | 40 | 40 | 11 | 52 | 106 | 0 | 5 | 1 | 0 | 0 | 3 | 3 | 3.97 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 57 | 0 | 3 | 1 | 2.28 | .278 | 1.14 | 6.8 | 3.4 | 10.0 | 71.0 | 54 | 18 | 18 | 10 | 27 | 79 | 0 | 7 | 1 | 0 | 0 | 1 | 5 | 3.79 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 53 | 0 | 5 | 3 | 4.28 | .285 | 1.18 | 8.1 | 2.5 | 7.7 | 61.0 | 55 | 30 | 29 | 9 | 17 | 52 | 0 | 9 | 3 | 0 | 0 | 1 | 0 | 4.10 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 38 | 0 | 0 | 4 | 7.64 | .404 | 1.98 | 10.0 | 8.0 | 12.6 | 35.1 | 39 | 30 | 30 | 6 | 31 | 49 | 0 | 3 | 0 | 0 | 0 | 2 | 4 | 5.26 |