| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 92 | 27 | 27 | 9 | 9 | 4.39 | .318 | 1.36 | 9.1 | 3.2 | 7.9 | 178.1 | 180 | 96 | 87 | 27 | 63 | 157 | 0 | 0 | 0 | 0 | 12 | 6 | 6 | 4.37 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 84 | 19 | 19 | 6 | 6 | 4.78 | .325 | 1.41 | 9.3 | 3.3 | 7.3 | 113.0 | 117 | 66 | 60 | 17 | 42 | 92 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 4.55 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 89 | 26 | 26 | 14 | 7 | 3.42 | .294 | 1.19 | 7.0 | 3.7 | 9.1 | 160.1 | 125 | 63 | 61 | 16 | 66 | 162 | 1 | 0 | 0 | 1 | 15 | 9 | 2 | 3.68 |
| SP | Keuchel, D.Keuchel, Dallas # >> | 27 | 2015 | L | 69 | 25 | 25 | 11 | 6 | 4.90 | .317 | 1.35 | 9.2 | 3.0 | 8.1 | 148.2 | 151 | 85 | 81 | 24 | 50 | 134 | 1 | 0 | 0 | 0 | 13 | 6 | 2 | 4.43 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 98 | 61 | 0 | 4 | 3 | 2.74 | .286 | 1.19 | 7.9 | 2.9 | 10.2 | 65.2 | 57 | 21 | 20 | 5 | 21 | 74 | 0 | 28 | 2 | 0 | 0 | 1 | 0 | 2.74 |
| RP | Soriano, R.Soriano, Rafael >> | 31 | 2010 | R | 80 | 69 | 0 | 7 | 1 | 3.05 | .308 | 1.31 | 8.5 | 3.4 | 7.0 | 91.1 | 86 | 33 | 31 | 7 | 34 | 71 | 0 | 2 | 4 | 0 | 0 | 2 | 0 | 3.63 |
| RP | Holland, G.Holland, Greg † >> | 27 | 2013 | R | 76 | 68 | 0 | 8 | 1 | 2.41 | .266 | 1.07 | 6.9 | 2.7 | 11.7 | 82.0 | 63 | 24 | 22 | 7 | 25 | 107 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 2.45 |
| RP | Balfour, G.Balfour, Grant >> | 35 | 2012 | R | 62 | 48 | 0 | 3 | 1 | 3.63 | .330 | 1.44 | 8.8 | 4.2 | 6.2 | 52.0 | 51 | 21 | 21 | 6 | 24 | 36 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 4.62 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 84 | 42 | 0 | 3 | 2 | 4.59 | .269 | 1.06 | 6.6 | 2.9 | 14.1 | 49.0 | 36 | 25 | 25 | 11 | 16 | 77 | 0 | 3 | 0 | 0 | 0 | 2 | 3 | 3.88 |