| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 98 | 23 | 23 | 11 | 5 | 3.82 | .286 | 1.17 | 7.2 | 3.4 | 10.6 | 153.1 | 122 | 65 | 65 | 17 | 58 | 181 | 1 | 0 | 0 | 1 | 13 | 4 | 3 | 3.29 |
| SP | Harvey, M.Harvey, Matt # >> | 24 | 2013 | R | 85 | 22 | 22 | 10 | 8 | 3.75 | .290 | 1.20 | 8.8 | 2.1 | 9.7 | 160.2 | 156 | 70 | 67 | 15 | 37 | 172 | 4 | 0 | 0 | 0 | 12 | 4 | 1 | 2.84 |
| SP | Weaver, J.Weaver, Jered # >> | 29 | 2011 | R | 71 | 22 | 22 | 5 | 8 | 5.58 | .359 | 1.64 | 11.6 | 3.2 | 7.2 | 137.0 | 176 | 87 | 85 | 21 | 49 | 110 | 0 | 0 | 0 | 0 | 7 | 5 | 3 | 4.57 |
| SP | Castillo, L.Castillo, Luis >> | 26 | 2019 | R | 50 | 22 | 22 | 4 | 9 | 6.26 | .372 | 1.75 | 10.9 | 5.0 | 8.4 | 110.2 | 133 | 80 | 77 | 16 | 61 | 103 | 0 | 0 | 0 | 0 | 7 | 3 | 3 | 4.76 |
| SP | Johnson, J.Johnson, Josh >> | 26 | 2010 | R | 39 | 22 | 22 | 8 | 6 | 4.56 | .327 | 1.45 | 10.1 | 2.9 | 10.2 | 142.0 | 160 | 74 | 72 | 18 | 46 | 161 | 1 | 0 | 0 | 1 | 10 | 1 | 5 | 3.37 |
| RP | Hendriks, L.Hendriks, Liam >> | 30 | 2019 | R | 40 | 32 | 0 | 1 | 3 | 6.12 | .378 | 1.79 | 11.3 | 5.1 | 9.0 | 32.1 | 40 | 22 | 22 | 3 | 18 | 32 | 0 | 3 | 2 | 0 | 0 | 1 | 7 | 4.00 |
| RP | Blanton, J.Blanton, Joe >> | 36 | 2016 | R | 30 | 30 | 0 | 5 | 1 | 2.23 | .248 | 0.94 | 5.3 | 3.3 | 9.5 | 36.1 | 21 | 9 | 9 | 3 | 13 | 38 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.22 |
| SP | Griffin, A.Griffin, A.J. >> | 25 | 2013 | R | 29 | 17 | 0 | 0 | 4 | 3.54 | .333 | 1.46 | 11.3 | 1.9 | 7.4 | 28.0 | 35 | 11 | 11 | 5 | 6 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.43 |