| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 8 | 16 | 5.20 | .320 | 1.40 | 8.7 | 3.9 | 8.3 | 193.2 | 187 | 119 | 112 | 16 | 84 | 179 | 0 | 0 | 0 | 0 | 17 | 3 | 7 | 3.58 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 33 | 33 | 12 | 15 | 4.12 | .299 | 1.26 | 9.3 | 2.0 | 5.0 | 229.1 | 236 | 114 | 105 | 19 | 52 | 128 | 9 | 0 | 0 | 1 | 17 | 5 | 2 | 3.71 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 32 | 6 | 15 | 5.76 | .339 | 1.54 | 10.6 | 3.2 | 4.6 | 178.0 | 210 | 130 | 114 | 27 | 64 | 91 | 1 | 0 | 0 | 0 | 14 | 0 | 2 | 5.03 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 31 | 30 | 10 | 9 | 4.18 | .318 | 1.38 | 8.1 | 4.4 | 7.5 | 148.2 | 133 | 75 | 69 | 12 | 72 | 124 | 0 | 1 | 0 | 0 | 7 | 3 | 1 | 3.90 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 71 | 0 | 5 | 4 | 1.72 | .266 | 1.07 | 4.8 | 4.9 | 9.8 | 94.0 | 50 | 18 | 18 | 5 | 51 | 102 | 0 | 27 | 3 | 0 | 0 | 1 | 0 | 3.18 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 80 | 0 | 3 | 1 | 4.46 | .324 | 1.42 | 8.6 | 4.3 | 8.8 | 84.2 | 80 | 43 | 42 | 7 | 40 | 82 | 0 | 2 | 1 | 0 | 0 | 2 | 5 | 3.63 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 84 | 0 | 7 | 3 | 3.57 | .323 | 1.41 | 9.3 | 3.5 | 6.7 | 90.2 | 93 | 40 | 36 | 8 | 35 | 67 | 0 | 2 | 5 | 0 | 0 | 2 | 1 | 3.90 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 3 | 1 | 0 | 1 | 8.68 | .391 | 1.93 | 14.0 | 4.0 | 5.0 | 9.1 | 14 | 9 | 9 | 1 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.67 |