| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 34 | 34 | 7 | 15 | 4.68 | .326 | 1.44 | 9.5 | 3.5 | 5.3 | 207.2 | 218 | 119 | 108 | 19 | 81 | 123 | 3 | 0 | 0 | 0 | 15 | 3 | 5 | 4.22 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 9 | 8 | 4.68 | .316 | 1.36 | 9.1 | 3.2 | 8.5 | 184.2 | 187 | 96 | 96 | 24 | 65 | 174 | 1 | 0 | 0 | 0 | 17 | 4 | 5 | 3.93 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 13 | 11 | 3.78 | .307 | 1.30 | 8.9 | 2.8 | 6.8 | 207.0 | 204 | 90 | 87 | 15 | 65 | 156 | 5 | 0 | 0 | 2 | 21 | 6 | 2 | 3.46 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 32 | 32 | 7 | 17 | 6.26 | .372 | 1.74 | 11.6 | 4.1 | 4.4 | 159.2 | 205 | 117 | 111 | 26 | 73 | 77 | 0 | 0 | 0 | 0 | 10 | 6 | 5 | 5.65 |
| SP | Coveleski, S.Coveleski, Stan # >> | 28 | 1917 | R | 62 | 30 | 30 | 10 | 11 | 4.45 | .306 | 1.28 | 8.2 | 3.3 | 4.1 | 166.0 | 152 | 87 | 82 | 18 | 61 | 76 | 0 | 0 | 0 | 0 | 16 | 7 | 3 | 4.72 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 89 | 0 | 5 | 4 | 3.06 | .270 | 1.10 | 7.8 | 2.1 | 8.3 | 123.1 | 107 | 51 | 42 | 8 | 29 | 114 | 0 | 7 | 4 | 0 | 0 | 1 | 2 | 2.72 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 75 | 0 | 2 | 5 | 3.93 | .291 | 1.22 | 7.5 | 3.6 | 9.8 | 91.2 | 76 | 40 | 40 | 11 | 36 | 99 | 0 | 9 | 0 | 0 | 0 | 1 | 2 | 3.62 |
| RP | Wetteland, J.Wetteland, John >> | 27 | 1993 | R | 39 | 53 | 0 | 3 | 6 | 5.68 | .338 | 1.53 | 9.4 | 4.4 | 7.3 | 63.1 | 66 | 40 | 40 | 10 | 31 | 51 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 4.92 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 6 | 3 | 2 | 1 | 5.95 | .359 | 1.58 | 8.5 | 6.2 | 11.4 | 19.2 | 18 | 14 | 13 | 3 | 13 | 24 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 4.89 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 36 | 0 | 3 | 7 | 6.87 | .405 | 2.01 | 13.6 | 4.7 | 6.9 | 57.2 | 86 | 52 | 44 | 12 | 30 | 44 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 5.88 |