| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 21 | 21 | 7 | 8 | 3.32 | .263 | 1.07 | 6.8 | 2.8 | 8.6 | 146.1 | 111 | 56 | 54 | 19 | 45 | 139 | 6 | 0 | 0 | 0 | 14 | 1 | 1 | 3.73 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 7 | 5 | 3.24 | .284 | 1.17 | 7.4 | 3.2 | 9.5 | 133.1 | 109 | 50 | 48 | 18 | 47 | 141 | 3 | 0 | 0 | 0 | 15 | 3 | 3 | 3.77 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 21 | 20 | 6 | 14 | 6.87 | .367 | 1.70 | 11.2 | 4.1 | 4.5 | 114.0 | 142 | 94 | 87 | 13 | 52 | 57 | 1 | 0 | 0 | 0 | 4 | 4 | 3 | 4.96 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 40 | 0 | 3 | 1 | 3.43 | .330 | 1.47 | 8.1 | 5.3 | 7.2 | 39.1 | 35 | 15 | 15 | 5 | 23 | 31 | 0 | 17 | 6 | 0 | 0 | 0 | 0 | 4.85 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 49 | 0 | 3 | 3 | 3.95 | .276 | 1.11 | 6.5 | 3.6 | 8.1 | 68.1 | 49 | 32 | 30 | 9 | 27 | 61 | 0 | 0 | 5 | 0 | 0 | 2 | 0 | 4.21 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 51 | 0 | 2 | 2 | 3.40 | .340 | 1.53 | 9.8 | 4.1 | 6.2 | 55.2 | 60 | 29 | 21 | 5 | 25 | 38 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 4.22 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 39 | 0 | 3 | 7 | 5.19 | .342 | 1.52 | 10.2 | 3.5 | 7.4 | 52.0 | 59 | 30 | 30 | 4 | 20 | 43 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.62 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 37 | 0 | 0 | 1 | 3.82 | .347 | 1.57 | 10.0 | 4.4 | 5.8 | 37.2 | 41 | 21 | 16 | 4 | 18 | 24 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 4.65 |