| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 14 | 11 | 3.82 | .296 | 1.23 | 9.0 | 2.1 | 8.6 | 221.2 | 221 | 96 | 94 | 24 | 52 | 212 | 1 | 0 | 0 | 0 | 22 | 7 | 0 | 3.29 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 9 | 16 | 5.06 | .340 | 1.52 | 11.0 | 2.8 | 3.6 | 163.2 | 199 | 103 | 92 | 18 | 50 | 65 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 4.63 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 11 | 13 | 4.88 | .321 | 1.41 | 9.7 | 3.0 | 4.3 | 219.2 | 237 | 126 | 119 | 24 | 73 | 105 | 8 | 0 | 0 | 1 | 10 | 1 | 5 | 4.48 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 31 | 31 | 12 | 14 | 4.58 | .323 | 1.40 | 9.4 | 3.2 | 4.8 | 220.0 | 230 | 118 | 112 | 29 | 79 | 117 | 10 | 0 | 0 | 1 | 14 | 6 | 5 | 4.81 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 82 | 0 | 5 | 6 | 3.27 | .287 | 1.19 | 7.7 | 3.1 | 7.9 | 115.2 | 99 | 49 | 42 | 11 | 39 | 101 | 0 | 8 | 8 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 80 | 0 | 6 | 6 | 3.68 | .292 | 1.20 | 8.4 | 2.4 | 7.5 | 93.0 | 87 | 39 | 38 | 6 | 25 | 78 | 0 | 7 | 5 | 0 | 0 | 3 | 0 | 3.06 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 44 | 0 | 2 | 4 | 6.35 | .398 | 1.94 | 11.0 | 6.6 | 8.2 | 45.1 | 55 | 32 | 32 | 8 | 33 | 41 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 5.82 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 33 | 0 | 0 | 2 | 2.77 | .272 | 1.12 | 6.8 | 3.4 | 8.9 | 61.2 | 46 | 19 | 19 | 6 | 23 | 60 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.44 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 17 | 0 | 3 | 1 | 5.08 | .331 | 1.45 | 8.7 | 4.5 | 3.2 | 28.1 | 27 | 18 | 16 | 3 | 14 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.29 |