| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 97 | 20 | 20 | 14 | 2 | 3.12 | .296 | 1.24 | 8.0 | 3.2 | 8.8 | 147.1 | 131 | 56 | 51 | 10 | 52 | 144 | 2 | 0 | 0 | 1 | 17 | 3 | 0 | 3.05 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 89 | 19 | 19 | 7 | 5 | 4.17 | .304 | 1.30 | 9.2 | 2.6 | 4.7 | 140.1 | 143 | 71 | 65 | 17 | 40 | 73 | 2 | 0 | 0 | 1 | 10 | 1 | 5 | 4.41 |
| SP | Alexander, P.Alexander, Pete # >> | 32 | 1919 | R | 75 | 19 | 19 | 11 | 7 | 4.01 | .311 | 1.34 | 9.6 | 2.4 | 4.6 | 146.0 | 156 | 80 | 65 | 16 | 39 | 75 | 8 | 0 | 0 | 2 | 9 | 3 | 1 | 4.26 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 68 | 18 | 18 | 5 | 10 | 6.96 | .378 | 1.77 | 12.3 | 3.7 | 6.1 | 98.1 | 134 | 88 | 76 | 13 | 40 | 66 | 0 | 0 | 0 | 0 | 7 | 5 | 3 | 4.76 |
| SP | Pfiester, J.Pfiester, Jack >> | 29 | 1907 | L | 65 | 18 | 18 | 8 | 7 | 4.47 | .310 | 1.33 | 9.2 | 2.9 | 5.6 | 116.2 | 118 | 66 | 58 | 10 | 37 | 72 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 3.89 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 54 | 0 | 2 | 3 | 1.89 | .280 | 1.13 | 6.1 | 4.2 | 10.6 | 52.1 | 35 | 15 | 11 | 2 | 24 | 61 | 0 | 5 | 3 | 0 | 0 | 2 | 5 | 2.65 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 91 | 41 | 0 | 1 | 4 | 2.63 | .276 | 1.15 | 5.3 | 5.1 | 9.6 | 48.0 | 28 | 17 | 14 | 1 | 27 | 51 | 0 | 3 | 2 | 0 | 0 | 0 | 7 | 2.83 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 86 | 39 | 0 | 1 | 1 | 5.29 | .336 | 1.52 | 9.6 | 4.2 | 8.7 | 32.1 | 34 | 21 | 19 | 7 | 15 | 31 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 5.31 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 78 | 26 | 0 | 2 | 1 | 2.78 | .336 | 1.52 | 7.6 | 6.2 | 7.9 | 32.1 | 27 | 12 | 10 | 2 | 22 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.13 |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 71 | 56 | 0 | 2 | 1 | 5.82 | .373 | 1.78 | 10.7 | 5.7 | 6.4 | 38.2 | 45 | 25 | 25 | 4 | 24 | 27 | 0 | 6 | 0 | 0 | 0 | 0 | 3 | 4.84 |