| SP | Verlander, J.Verlander, Justin $$ >> | 36 | 2019 | R | 99 | 20 | 20 | 10 | 9 | 3.57 | .269 | 1.10 | 7.6 | 2.3 | 8.3 | 163.2 | 138 | 65 | 65 | 18 | 42 | 150 | 9 | 0 | 0 | 2 | 11 | 1 | 2 | 3.39 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 19 | 19 | 6 | 10 | 4.50 | .300 | 1.26 | 9.1 | 2.3 | 5.7 | 148.0 | 149 | 79 | 74 | 21 | 37 | 93 | 6 | 0 | 0 | 0 | 10 | 4 | 4 | 4.42 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 19 | 19 | 8 | 9 | 4.16 | .313 | 1.33 | 8.8 | 3.2 | 4.5 | 140.2 | 137 | 69 | 65 | 14 | 50 | 70 | 5 | 0 | 0 | 1 | 10 | 5 | 5 | 4.48 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 19 | 19 | 5 | 7 | 4.74 | .296 | 1.25 | 8.6 | 2.7 | 5.2 | 136.2 | 130 | 72 | 72 | 19 | 41 | 78 | 2 | 0 | 0 | 0 | 9 | 1 | 5 | 4.60 |
| RP | Chapman, A.Chapman, Aroldis $ >> | 37 | 2025 | L | 96 | 46 | 0 | 2 | 1 | 2.56 | .265 | 1.08 | 6.1 | 3.8 | 9.5 | 52.2 | 35 | 15 | 15 | 5 | 22 | 55 | 0 | 8 | 1 | 0 | 0 | 0 | 2 | 3.40 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 77 | 23 | 0 | 5 | 0 | 1.24 | .216 | 0.83 | 3.7 | 3.7 | 9.0 | 29.0 | 12 | 4 | 4 | 2 | 12 | 29 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.14 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 11 | 0 | 0 | 1 | 3.14 | .295 | 1.19 | 8.4 | 2.6 | 6.4 | 14.1 | 13 | 5 | 5 | 2 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 10 | 0 | 2 | 0 | 1.00 | .308 | 1.33 | 6.0 | 6.0 | 7.0 | 9.0 | 6 | 1 | 1 | 0 | 6 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.44 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 9 | 0 | 1 | 1 | 6.17 | .375 | 1.80 | 14.7 | 2.5 | 9.0 | 11.2 | 18 | 8 | 8 | 0 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.82 |