| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 26 | 26 | 9 | 12 | 3.82 | .268 | 1.09 | 7.6 | 2.3 | 8.0 | 188.2 | 158 | 82 | 80 | 27 | 48 | 167 | 5 | 0 | 0 | 2 | 17 | 1 | 1 | 3.87 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 25 | 25 | 8 | 10 | 4.87 | .324 | 1.41 | 9.4 | 3.3 | 8.2 | 151.2 | 158 | 84 | 82 | 32 | 56 | 137 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 5.13 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 25 | 25 | 5 | 12 | 5.17 | .337 | 1.50 | 9.5 | 4.1 | 4.4 | 132.1 | 139 | 79 | 76 | 18 | 60 | 65 | 0 | 0 | 0 | 0 | 9 | 3 | 4 | 5.22 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 25 | 25 | 8 | 13 | 3.91 | .321 | 1.41 | 9.7 | 3.0 | 4.7 | 195.2 | 210 | 94 | 85 | 21 | 65 | 102 | 10 | 0 | 0 | 1 | 14 | 3 | 3 | 4.40 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 49 | 0 | 1 | 4 | 2.32 | .253 | 1.02 | 7.5 | 1.6 | 8.0 | 62.0 | 52 | 17 | 16 | 4 | 11 | 55 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.60 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 39 | 0 | 3 | 0 | 3.67 | .313 | 1.37 | 6.1 | 6.4 | 11.0 | 41.2 | 28 | 19 | 17 | 7 | 29 | 50 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.90 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 28 | 0 | 3 | 3 | 4.76 | .336 | 1.52 | 8.7 | 5.1 | 7.7 | 28.1 | 27 | 15 | 15 | 3 | 16 | 24 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.39 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 28 | 0 | 0 | 2 | 5.34 | .273 | 1.09 | 7.3 | 2.5 | 8.7 | 32.0 | 26 | 19 | 19 | 6 | 9 | 31 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.44 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 8 | 0 | 0 | 1 | 1.64 | .340 | 1.55 | 9.0 | 4.9 | 4.9 | 11.0 | 11 | 2 | 2 | 0 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.55 |