| SP | Walsh, E.Walsh, Ed # $$ >> | 29 | 1910 | R | 93 | 20 | 20 | 10 | 6 | 3.13 | .267 | 1.06 | 7.3 | 2.3 | 5.1 | 144.0 | 117 | 54 | 50 | 11 | 36 | 81 | 6 | 0 | 0 | 2 | 13 | 4 | 0 | 3.70 |
| SP | Arrieta, J.Arrieta, Jake $$ >> | 29 | 2015 | R | 92 | 20 | 20 | 4 | 12 | 4.96 | .306 | 1.31 | 8.0 | 3.8 | 6.6 | 121.2 | 108 | 69 | 67 | 19 | 51 | 89 | 2 | 0 | 0 | 0 | 8 | 2 | 2 | 4.88 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 81 | 19 | 19 | 10 | 4 | 3.44 | .264 | 1.07 | 6.1 | 3.5 | 7.7 | 115.0 | 78 | 44 | 44 | 8 | 45 | 98 | 0 | 0 | 0 | 0 | 10 | 1 | 6 | 3.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 19 | 19 | 5 | 4 | 4.24 | .317 | 1.39 | 8.6 | 4.0 | 8.3 | 108.1 | 103 | 55 | 51 | 14 | 48 | 100 | 0 | 0 | 0 | 0 | 10 | 0 | 4 | 4.17 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 19 | 19 | 3 | 7 | 5.37 | .344 | 1.54 | 8.7 | 5.2 | 8.1 | 107.1 | 103 | 67 | 64 | 14 | 62 | 96 | 1 | 0 | 0 | 0 | 7 | 4 | 4 | 4.76 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 39 | 0 | 1 | 1 | 2.90 | .280 | 1.14 | 5.6 | 4.7 | 7.0 | 40.1 | 25 | 13 | 13 | 6 | 21 | 31 | 0 | 29 | 5 | 0 | 0 | 1 | 0 | 5.05 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 57 | 0 | 9 | 0 | 3.28 | .260 | 1.05 | 5.7 | 3.9 | 7.9 | 49.1 | 31 | 18 | 18 | 5 | 21 | 43 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.86 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 42 | 0 | 0 | 2 | 4.40 | .338 | 1.50 | 8.0 | 5.8 | 10.9 | 28.2 | 25 | 14 | 14 | 4 | 18 | 34 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.46 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 8 | 0 | 0 | 0 | 4.26 | .269 | 1.11 | 9.0 | 1.5 | 10.5 | 6.1 | 6 | 3 | 3 | 2 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 29 | 0 | 3 | 2 | 2.63 | .281 | 1.17 | 7.3 | 3.3 | 4.3 | 27.1 | 22 | 8 | 8 | 5 | 10 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.56 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 52 | 0 | 4 | 0 | 4.50 | .268 | 1.08 | 7.9 | 1.8 | 7.0 | 40.0 | 35 | 23 | 20 | 4 | 8 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.43 |