| SP | Bender, C.Bender, Chief † >> | 26 | 1910 | R | 84 | 39 | 39 | 20 | 12 | 3.18 | .282 | 1.15 | 8.2 | 2.1 | 4.8 | 303.0 | 277 | 115 | 107 | 18 | 72 | 160 | 12 | 0 | 0 | 2 | 25 | 8 | 3 | 3.51 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 79 | 37 | 37 | 18 | 10 | 3.70 | .300 | 1.24 | 8.7 | 2.4 | 5.9 | 255.2 | 247 | 110 | 105 | 23 | 69 | 167 | 3 | 0 | 0 | 1 | 23 | 12 | 6 | 3.82 |
| SP | Morgan, C.Morgan, Cy † >> | 31 | 1909 | R | 74 | 36 | 36 | 19 | 12 | 3.09 | .287 | 1.18 | 7.1 | 3.6 | 4.2 | 285.1 | 224 | 107 | 98 | 14 | 113 | 133 | 16 | 0 | 0 | 5 | 21 | 8 | 7 | 3.98 |
| SP | Duchscherer, J.Duchscherer, Justin # >> | 31 | 2008 | R | 64 | 34 | 34 | 15 | 11 | 4.65 | .318 | 1.36 | 9.2 | 3.1 | 5.3 | 216.2 | 221 | 116 | 112 | 24 | 74 | 128 | 2 | 0 | 0 | 0 | 19 | 8 | 5 | 4.40 |
| CL | Doolittle, S.Doolittle, Sean >> | 27 | 2014 | L | 94 | 62 | 0 | 1 | 2 | 4.04 | .295 | 1.24 | 8.8 | 2.5 | 8.2 | 55.2 | 54 | 29 | 25 | 4 | 15 | 50 | 0 | 44 | 5 | 0 | 0 | 1 | 0 | 3.00 |
| SU | Devine, J.Devine, Joey >> | 25 | 2008 | R | 90 | 44 | 0 | 2 | 1 | 2.86 | .298 | 1.25 | 6.3 | 4.9 | 9.2 | 44.0 | 31 | 14 | 14 | 2 | 24 | 45 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.25 |
| RP | Madson, R.Madson, Ryan >> | 37 | 2017 | R | 85 | 27 | 0 | 7 | 1 | 4.05 | .328 | 1.46 | 11.4 | 2.1 | 8.7 | 26.2 | 33 | 12 | 12 | 4 | 6 | 25 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Wendelken, J.Wendelken, J.B. >> | 26 | 2019 | R | 73 | 17 | 0 | 3 | 1 | 3.38 | .264 | 0.98 | 5.6 | 3.4 | 12.4 | 21.1 | 13 | 8 | 8 | 2 | 8 | 29 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.90 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 72 | 18 | 0 | 1 | 2 | 6.63 | .360 | 1.68 | 7.1 | 8.1 | 6.6 | 19.0 | 15 | 15 | 14 | 1 | 17 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.89 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 22 | 0 | 0 | 0 | 0.33 | .229 | 0.89 | 5.0 | 3.0 | 10.0 | 27.0 | 15 | 1 | 1 | 0 | 9 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.78 |
| SP | Samardzija, J.Samardzija, Jeff >> | 29 | 2014 | R | 72 | 33 | 32 | 9 | 18 | 4.13 | .310 | 1.32 | 9.4 | 2.5 | 7.0 | 231.0 | 241 | 121 | 106 | 25 | 64 | 180 | 7 | 0 | 0 | 2 | 17 | 7 | 2 | 3.77 |