| SP | Lolich, M.Lolich, Mickey >> | 27 | 1967 | L | 56 | 34 | 34 | 6 | 19 | 5.35 | .353 | 1.60 | 11.3 | 3.1 | 6.5 | 186.2 | 234 | 120 | 111 | 18 | 65 | 135 | 1 | 0 | 0 | 1 | 16 | 6 | 7 | 3.95 |
| SP | Verlander, J.Verlander, Justin # >> | 32 | 2015 | R | 52 | 32 | 32 | 8 | 16 | 5.51 | .324 | 1.44 | 10.5 | 2.4 | 6.0 | 188.0 | 219 | 115 | 115 | 28 | 51 | 125 | 0 | 0 | 0 | 0 | 13 | 0 | 3 | 4.42 |
| SP | Wilson, E.Wilson, Earl >> | 34 | 1968 | R | 40 | 32 | 32 | 6 | 16 | 6.46 | .363 | 1.67 | 11.5 | 3.6 | 5.4 | 186.2 | 238 | 144 | 134 | 26 | 74 | 111 | 2 | 0 | 0 | 0 | 9 | 7 | 3 | 4.93 |
| SP | McLain, D.McLain, Denny >> | 22 | 1966 | R | 42 | 31 | 30 | 10 | 9 | 4.76 | .340 | 1.53 | 8.8 | 5.0 | 5.3 | 181.2 | 177 | 101 | 96 | 20 | 101 | 107 | 1 | 0 | 0 | 1 | 15 | 3 | 5 | 4.98 |
| RP | Skubal, T.Skubal, Tarik >> | 26 | 2023 | L | 70 | 85 | 0 | 7 | 1 | 3.97 | .311 | 1.33 | 8.8 | 3.2 | 7.7 | 111.0 | 109 | 50 | 49 | 11 | 39 | 95 | 0 | 1 | 2 | 0 | 0 | 2 | 3 | 3.68 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 84 | 72 | 0 | 4 | 3 | 3.64 | .309 | 1.34 | 7.3 | 4.9 | 8.4 | 76.2 | 62 | 31 | 31 | 5 | 41 | 71 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.61 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 74 | 44 | 0 | 3 | 2 | 2.61 | .266 | 1.06 | 6.4 | 3.1 | 6.4 | 69.0 | 49 | 21 | 20 | 5 | 24 | 49 | 0 | 2 | 1 | 0 | 0 | 2 | 8 | 3.65 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 53 | 36 | 0 | 1 | 1 | 5.27 | .362 | 1.69 | 11.1 | 4.2 | 5.6 | 56.1 | 69 | 35 | 33 | 5 | 26 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.36 |
| SU | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 59 | 54 | 0 | 0 | 7 | 5.43 | .332 | 1.46 | 9.8 | 3.5 | 6.4 | 69.2 | 75 | 44 | 42 | 14 | 27 | 49 | 0 | 8 | 8 | 0 | 0 | 2 | 1 | 5.48 |
| SP | Weaver, J.Weaver, Jeff >> | 26 | 2002 | R | 29 | 2 | 1 | 2 | 0 | 3.00 | .341 | 1.44 | 5.0 | 8.0 | 4.0 | 9.0 | 5 | 3 | 3 | 1 | 8 | 4 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.56 |
| CL | Fister, D.Fister, Doug >> | 27 | 2011 | R | 60 | 54 | 0 | 6 | 13 | 3.79 | .282 | 1.14 | 7.9 | 2.3 | 5.3 | 102.0 | 90 | 44 | 43 | 13 | 26 | 60 | 0 | 26 | 8 | 0 | 0 | 4 | 0 | 4.36 |