| SP | Lolich, M.Lolich, Mickey >> | 27 | 1967 | L | 56 | 10 | 10 | 1 | 6 | 6.62 | .371 | 1.75 | 12.6 | 3.2 | 6.1 | 50.1 | 70 | 39 | 37 | 6 | 18 | 34 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 4.34 |
| SP | Verlander, J.Verlander, Justin # >> | 32 | 2015 | R | 52 | 10 | 10 | 3 | 4 | 6.79 | .361 | 1.70 | 12.1 | 3.2 | 6.1 | 53.0 | 71 | 40 | 40 | 7 | 19 | 36 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 4.43 |
| SP | Wilson, E.Wilson, Earl >> | 34 | 1968 | R | 40 | 10 | 10 | 2 | 6 | 7.19 | .380 | 1.81 | 12.4 | 4.0 | 4.6 | 61.1 | 84 | 52 | 49 | 8 | 27 | 31 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 5.11 |
| SP | McLain, D.McLain, Denny >> | 22 | 1966 | R | 42 | 9 | 8 | 2 | 2 | 6.65 | .382 | 1.84 | 11.3 | 5.5 | 4.7 | 44.2 | 55 | 35 | 33 | 5 | 27 | 23 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 5.34 |
| RP | Skubal, T.Skubal, Tarik >> | 26 | 2023 | L | 70 | 26 | 0 | 1 | 0 | 2.21 | .281 | 1.15 | 8.5 | 2.0 | 9.0 | 36.2 | 34 | 9 | 9 | 4 | 8 | 36 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.19 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 84 | 21 | 0 | 1 | 0 | 3.60 | .306 | 1.32 | 7.2 | 4.7 | 7.6 | 25.0 | 20 | 10 | 10 | 2 | 13 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.92 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 74 | 18 | 0 | 1 | 0 | 1.67 | .229 | 0.81 | 5.0 | 2.3 | 6.3 | 27.0 | 15 | 6 | 5 | 2 | 7 | 19 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.56 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 53 | 13 | 0 | 1 | 0 | 5.59 | .389 | 1.91 | 13.3 | 4.3 | 6.2 | 19.1 | 28 | 14 | 12 | 3 | 9 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.11 |
| SU | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 59 | 16 | 0 | 0 | 4 | 9.00 | .386 | 1.89 | 14.5 | 2.5 | 6.0 | 18.0 | 29 | 19 | 18 | 5 | 5 | 12 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 6.11 |
| SP | Weaver, J.Weaver, Jeff >> | 26 | 2002 | R | 29 | 2 | 1 | 2 | 0 | 3.00 | .341 | 1.44 | 5.0 | 8.0 | 4.0 | 9.0 | 5 | 3 | 3 | 1 | 8 | 4 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.56 |
| CL | Fister, D.Fister, Doug >> | 27 | 2011 | R | 60 | 18 | 0 | 2 | 4 | 3.41 | .290 | 1.17 | 7.9 | 2.6 | 4.2 | 34.1 | 30 | 13 | 13 | 1 | 10 | 16 | 0 | 10 | 2 | 0 | 0 | 2 | 0 | 3.50 |