| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 87 | 25 | 25 | 11 | 6 | 3.90 | .290 | 1.21 | 9.2 | 1.7 | 10.0 | 161.1 | 164 | 71 | 70 | 8 | 31 | 179 | 1 | 0 | 0 | 0 | 15 | 3 | 3 | 2.06 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 81 | 24 | 24 | 14 | 5 | 3.41 | .305 | 1.31 | 8.3 | 3.5 | 6.3 | 190.0 | 175 | 79 | 72 | 16 | 74 | 132 | 9 | 0 | 0 | 1 | 15 | 1 | 3 | 3.89 |
| SP | Scherzer, M.Scherzer, Max † >> | 29 | 2013 | R | 73 | 24 | 24 | 17 | 4 | 3.70 | .304 | 1.29 | 7.9 | 3.8 | 8.9 | 167.2 | 146 | 74 | 69 | 15 | 70 | 165 | 2 | 0 | 0 | 1 | 16 | 4 | 3 | 3.52 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 70 | 23 | 23 | 12 | 5 | 4.11 | .313 | 1.34 | 9.3 | 2.7 | 9.0 | 138.0 | 143 | 67 | 63 | 17 | 42 | 138 | 1 | 0 | 0 | 1 | 12 | 4 | 0 | 3.60 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 84 | 54 | 0 | 4 | 0 | 3.24 | .308 | 1.32 | 7.8 | 4.2 | 9.4 | 66.2 | 57 | 24 | 24 | 6 | 31 | 69 | 0 | 10 | 3 | 0 | 0 | 1 | 0 | 3.55 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 80 | 53 | 0 | 7 | 4 | 3.15 | .271 | 1.12 | 5.7 | 4.4 | 8.6 | 60.0 | 38 | 21 | 21 | 2 | 29 | 57 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 2.98 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 71 | 36 | 0 | 0 | 3 | 4.57 | .366 | 1.68 | 9.8 | 5.4 | 5.2 | 43.1 | 47 | 24 | 22 | 7 | 26 | 25 | 0 | 4 | 4 | 0 | 0 | 2 | 5 | 5.91 |
| SP | Garcia, R.Garcia, Rony >> | 24 | 2022 | R | 53 | 24 | 20 | 0 | 6 | 5.68 | .334 | 1.51 | 10.1 | 3.6 | 6.2 | 77.2 | 86 | 50 | 49 | 12 | 31 | 53 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 4.86 |