| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 24 | 24 | 7 | 10 | 4.20 | .342 | 1.53 | 9.6 | 4.2 | 9.8 | 154.1 | 164 | 73 | 72 | 18 | 72 | 168 | 4 | 0 | 0 | 1 | 14 | 5 | 5 | 3.84 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 25 | 25 | 10 | 10 | 5.01 | .325 | 1.42 | 9.7 | 3.0 | 8.4 | 142.0 | 153 | 82 | 79 | 19 | 48 | 132 | 0 | 0 | 0 | 0 | 13 | 4 | 3 | 3.98 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 24 | 24 | 8 | 8 | 4.49 | .299 | 1.23 | 8.6 | 2.4 | 6.3 | 126.1 | 121 | 67 | 63 | 20 | 34 | 88 | 0 | 0 | 0 | 0 | 8 | 7 | 2 | 4.64 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 75 | 0 | 6 | 3 | 4.10 | .268 | 1.06 | 6.8 | 2.9 | 8.7 | 85.2 | 64 | 40 | 39 | 16 | 27 | 82 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.58 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 78 | 0 | 6 | 2 | 4.07 | .311 | 1.34 | 8.0 | 4.1 | 10.0 | 55.1 | 49 | 26 | 25 | 4 | 25 | 61 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.15 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 46 | 0 | 2 | 6 | 5.48 | .361 | 1.65 | 8.6 | 6.3 | 6.5 | 46.0 | 44 | 28 | 28 | 9 | 32 | 33 | 0 | 22 | 8 | 0 | 0 | 2 | 1 | 6.33 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 62 | 0 | 3 | 2 | 4.04 | .286 | 1.19 | 9.1 | 1.6 | 7.7 | 69.0 | 70 | 31 | 31 | 10 | 12 | 59 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 46 | 0 | 0 | 3 | 4.15 | .316 | 1.36 | 7.3 | 5.0 | 9.0 | 43.1 | 35 | 20 | 20 | 5 | 24 | 43 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.26 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 39 | 0 | 2 | 2 | 5.19 | .302 | 1.30 | 10.9 | 1.1 | 12.7 | 34.2 | 41 | 20 | 20 | 6 | 4 | 48 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.82 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 27 | 0 | 1 | 1 | 3.51 | .287 | 1.21 | 8.3 | 2.9 | 5.0 | 25.2 | 23 | 10 | 10 | 4 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.92 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 55 | 60 | 0 | 2 | 1 | 4.73 | .313 | 1.35 | 8.2 | 4.1 | 9.8 | 53.1 | 48 | 28 | 28 | 10 | 24 | 58 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.68 |