| SP | Clemens, R.Clemens, Roger † >> | 43 | 2005 | R | 94 | 26 | 26 | 14 | 5 | 2.92 | .290 | 1.21 | 7.2 | 3.7 | 6.3 | 166.1 | 132 | 56 | 54 | 15 | 69 | 117 | 0 | 0 | 0 | 0 | 18 | 3 | 3 | 4.07 |
| SP | Hamels, C.Hamels, Cole † # >> | 25 | 2008 | L | 72 | 25 | 25 | 15 | 4 | 3.87 | .314 | 1.33 | 9.2 | 2.7 | 6.9 | 151.0 | 155 | 69 | 65 | 23 | 46 | 116 | 1 | 0 | 0 | 0 | 15 | 6 | 0 | 4.48 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 25 | 25 | 12 | 9 | 4.47 | .315 | 1.36 | 8.9 | 3.3 | 7.3 | 147.0 | 146 | 74 | 73 | 20 | 54 | 120 | 0 | 0 | 0 | 0 | 15 | 3 | 4 | 4.30 |
| SP | Burkett, J.Burkett, John # >> | 37 | 2001 | R | 49 | 24 | 24 | 6 | 13 | 6.88 | .377 | 1.76 | 11.4 | 4.5 | 6.4 | 136.0 | 172 | 110 | 104 | 24 | 68 | 96 | 1 | 0 | 0 | 0 | 6 | 7 | 3 | 5.54 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 38 | 24 | 24 | 9 | 12 | 6.75 | .368 | 1.72 | 10.7 | 4.8 | 7.6 | 133.1 | 158 | 101 | 100 | 27 | 71 | 112 | 1 | 0 | 0 | 0 | 5 | 4 | 2 | 5.65 |
| RP | Neshek, P.Neshek, Pat † >> | 26 | 2006 | R | 94 | 64 | 0 | 6 | 3 | 2.80 | .272 | 1.12 | 7.9 | 2.3 | 12.1 | 96.1 | 84 | 34 | 30 | 13 | 24 | 129 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 2.82 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 48 | 48 | 0 | 4 | 1 | 4.05 | .271 | 1.12 | 6.6 | 3.5 | 6.9 | 60.0 | 44 | 28 | 27 | 9 | 23 | 46 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 4.57 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 37 | 33 | 0 | 1 | 3 | 3.41 | .293 | 1.22 | 6.3 | 4.6 | 7.5 | 37.0 | 26 | 16 | 14 | 3 | 19 | 31 | 0 | 8 | 1 | 0 | 0 | 1 | 2 | 4.00 |
| RP | Graves, D.Graves, Danny >> | 29 | 2002 | R | 1 | 33 | 0 | 1 | 1 | 4.68 | .335 | 1.44 | 8.1 | 4.9 | 8.6 | 42.1 | 38 | 22 | 22 | 4 | 23 | 40 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 4.19 |