| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 85 | 35 | 35 | 13 | 9 | 4.00 | .300 | 1.25 | 8.4 | 2.9 | 8.8 | 236.0 | 221 | 106 | 105 | 36 | 75 | 231 | 0 | 0 | 0 | 0 | 22 | 7 | 4 | 4.07 |
| SP | Verlander, J.Verlander, Justin # >> | 28 | 2011 | R | 82 | 34 | 34 | 15 | 10 | 3.84 | .284 | 1.17 | 7.4 | 3.2 | 7.8 | 260.0 | 214 | 117 | 111 | 26 | 91 | 226 | 9 | 0 | 0 | 1 | 19 | 5 | 11 | 3.67 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 81 | 33 | 33 | 16 | 13 | 3.96 | .293 | 1.21 | 8.4 | 2.5 | 6.5 | 252.1 | 236 | 114 | 111 | 35 | 69 | 182 | 15 | 0 | 0 | 2 | 17 | 9 | 1 | 4.29 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 76 | 33 | 33 | 13 | 11 | 5.06 | .317 | 1.36 | 8.8 | 3.5 | 8.7 | 222.1 | 216 | 127 | 125 | 23 | 86 | 214 | 4 | 0 | 0 | 1 | 16 | 8 | 6 | 3.69 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 73 | 31 | 31 | 15 | 10 | 4.80 | .309 | 1.32 | 8.8 | 3.0 | 8.6 | 195.0 | 191 | 104 | 104 | 28 | 66 | 186 | 1 | 0 | 0 | 1 | 14 | 4 | 5 | 4.04 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 88 | 78 | 0 | 10 | 1 | 3.36 | .282 | 1.15 | 6.2 | 4.2 | 8.4 | 91.0 | 63 | 34 | 34 | 11 | 42 | 85 | 0 | 5 | 5 | 0 | 0 | 2 | 0 | 4.15 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 77 | 78 | 0 | 3 | 3 | 3.25 | .305 | 1.27 | 6.6 | 5.0 | 8.1 | 63.2 | 46 | 23 | 23 | 2 | 35 | 57 | 0 | 7 | 2 | 0 | 0 | 3 | 2 | 3.41 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 69 | 67 | 0 | 3 | 4 | 5.01 | .321 | 1.37 | 7.9 | 4.6 | 8.3 | 55.2 | 48 | 31 | 31 | 8 | 28 | 51 | 0 | 9 | 3 | 0 | 0 | 3 | 6 | 4.73 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 65 | 38 | 0 | 3 | 3 | 2.75 | .208 | 0.79 | 4.8 | 2.3 | 8.8 | 39.1 | 21 | 13 | 12 | 3 | 10 | 38 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 2.82 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 60 | 58 | 0 | 6 | 3 | 3.40 | .304 | 1.29 | 9.4 | 2.2 | 8.8 | 45.0 | 47 | 17 | 17 | 8 | 11 | 44 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 4.16 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 47 | 33 | 0 | 1 | 1 | 2.85 | .301 | 1.29 | 8.8 | 2.9 | 6.8 | 41.0 | 40 | 15 | 13 | 7 | 13 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.66 |