| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 85 | 7 | 7 | 1 | 2 | 3.70 | .308 | 1.32 | 8.6 | 3.4 | 9.0 | 48.2 | 46 | 20 | 20 | 5 | 18 | 48 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 3.54 |
| SP | Verlander, J.Verlander, Justin # >> | 28 | 2011 | R | 82 | 6 | 6 | 2 | 2 | 5.88 | .330 | 1.45 | 9.2 | 4.0 | 7.5 | 41.1 | 42 | 28 | 27 | 6 | 18 | 34 | 1 | 0 | 0 | 1 | 1 | 1 | 2 | 4.63 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 81 | 6 | 6 | 4 | 2 | 2.91 | .265 | 1.06 | 7.6 | 2.1 | 6.6 | 52.2 | 44 | 17 | 17 | 6 | 12 | 38 | 5 | 0 | 0 | 0 | 4 | 1 | 0 | 3.79 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 76 | 7 | 7 | 3 | 3 | 5.52 | .333 | 1.48 | 8.4 | 4.9 | 9.8 | 44.0 | 41 | 27 | 27 | 7 | 24 | 48 | 1 | 0 | 0 | 0 | 4 | 1 | 1 | 4.59 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 73 | 6 | 6 | 2 | 3 | 4.50 | .283 | 1.18 | 7.8 | 2.8 | 6.4 | 38.0 | 33 | 19 | 19 | 8 | 12 | 27 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 5.26 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 88 | 15 | 0 | 0 | 0 | 6.06 | .372 | 1.78 | 8.4 | 7.9 | 10.7 | 16.1 | 15 | 11 | 11 | 2 | 14 | 19 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 77 | 13 | 0 | 1 | 1 | 3.72 | .326 | 1.34 | 8.0 | 5.0 | 9.0 | 9.2 | 8 | 4 | 4 | 0 | 5 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.00 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 69 | 14 | 0 | 1 | 2 | 4.38 | .288 | 1.22 | 8.3 | 3.0 | 7.5 | 12.1 | 11 | 6 | 6 | 2 | 4 | 10 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 65 | 6 | 0 | 1 | 0 | 2.16 | .219 | 0.84 | 5.6 | 2.3 | 9.0 | 8.1 | 5 | 2 | 2 | 0 | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.75 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 60 | 10 | 0 | 1 | 0 | 0.87 | .139 | 0.48 | 3.6 | 0.9 | 10.8 | 10.1 | 4 | 1 | 1 | 1 | 1 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.20 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 47 | 9 | 0 | 1 | 0 | 4.22 | .304 | 1.31 | 12.6 | 0.0 | 7.2 | 10.2 | 14 | 5 | 5 | 3 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.30 |