| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 12 | 12 | 3 | 6 | 4.17 | .297 | 1.25 | 8.2 | 3.1 | 6.3 | 90.2 | 82 | 49 | 42 | 9 | 31 | 63 | 2 | 0 | 0 | 0 | 6 | 2 | 2 | 4.00 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 11 | 11 | 6 | 0 | 1.88 | .254 | 1.01 | 6.1 | 3.0 | 4.4 | 81.1 | 55 | 18 | 17 | 3 | 27 | 40 | 1 | 0 | 0 | 0 | 9 | 1 | 0 | 3.53 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 11 | 11 | 3 | 5 | 4.42 | .323 | 1.43 | 9.0 | 3.9 | 9.8 | 71.1 | 71 | 40 | 35 | 7 | 31 | 77 | 1 | 0 | 0 | 0 | 6 | 0 | 5 | 3.42 |
| CL | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 15 | 0 | 1 | 1 | 3.29 | .349 | 1.61 | 9.0 | 6.2 | 8.3 | 13.2 | 13 | 6 | 5 | 1 | 9 | 12 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.23 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 18 | 0 | 2 | 0 | 3.27 | .250 | 1.00 | 4.9 | 4.1 | 6.5 | 11.0 | 6 | 4 | 4 | 0 | 5 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 22 | 0 | 1 | 1 | 2.11 | .289 | 1.22 | 7.3 | 3.9 | 9.4 | 21.1 | 17 | 5 | 5 | 0 | 9 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.19 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 20 | 0 | 3 | 2 | 3.43 | .323 | 1.43 | 8.1 | 4.7 | 11.1 | 21.0 | 19 | 14 | 8 | 2 | 11 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.33 |