| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 28 | 28 | 9 | 10 | 3.73 | .288 | 1.18 | 8.2 | 2.4 | 9.4 | 188.0 | 171 | 83 | 78 | 29 | 51 | 196 | 2 | 0 | 0 | 0 | 17 | 6 | 0 | 3.83 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 27 | 27 | 7 | 15 | 3.99 | .308 | 1.30 | 9.0 | 2.8 | 4.3 | 191.2 | 191 | 97 | 85 | 11 | 59 | 91 | 7 | 0 | 0 | 3 | 14 | 6 | 4 | 3.82 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 27 | 27 | 7 | 12 | 5.54 | .332 | 1.46 | 9.3 | 3.8 | 4.4 | 169.0 | 175 | 108 | 104 | 19 | 72 | 82 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 4.86 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 27 | 27 | 10 | 10 | 4.15 | .331 | 1.44 | 9.1 | 3.9 | 3.8 | 164.2 | 166 | 90 | 76 | 16 | 71 | 69 | 0 | 0 | 0 | 0 | 15 | 7 | 2 | 4.85 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 70 | 0 | 7 | 5 | 4.25 | .275 | 1.12 | 7.3 | 2.8 | 10.1 | 97.1 | 79 | 49 | 46 | 13 | 30 | 109 | 0 | 7 | 3 | 0 | 0 | 2 | 4 | 3.48 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 61 | 0 | 3 | 6 | 4.79 | .323 | 1.43 | 11.0 | 1.9 | 7.8 | 77.0 | 94 | 42 | 41 | 7 | 16 | 67 | 0 | 9 | 4 | 0 | 0 | 0 | 1 | 3.06 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 47 | 0 | 0 | 3 | 4.87 | .312 | 1.34 | 9.6 | 2.5 | 9.0 | 57.1 | 61 | 33 | 31 | 5 | 16 | 57 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.04 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 18 | 0 | 0 | 2 | 5.59 | .396 | 1.91 | 12.8 | 4.7 | 5.7 | 19.1 | 27 | 12 | 12 | 3 | 10 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.53 |