| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 28 | 28 | 13 | 10 | 3.80 | .300 | 1.26 | 8.3 | 3.1 | 8.2 | 203.2 | 187 | 92 | 86 | 16 | 70 | 185 | 4 | 0 | 0 | 1 | 16 | 5 | 5 | 3.31 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 28 | 28 | 8 | 12 | 6.19 | .347 | 1.55 | 10.1 | 3.8 | 9.3 | 157.0 | 177 | 118 | 108 | 18 | 67 | 162 | 1 | 0 | 0 | 1 | 12 | 6 | 1 | 3.82 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 27 | 27 | 10 | 14 | 5.72 | .336 | 1.48 | 11.2 | 2.1 | 5.1 | 170.0 | 212 | 111 | 108 | 20 | 40 | 97 | 1 | 0 | 0 | 0 | 12 | 6 | 4 | 4.20 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 25 | 25 | 13 | 9 | 4.18 | .332 | 1.47 | 8.7 | 4.6 | 5.9 | 176.2 | 170 | 90 | 82 | 22 | 89 | 115 | 6 | 0 | 0 | 0 | 14 | 4 | 1 | 4.90 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 43 | 0 | 1 | 3 | 5.54 | .345 | 1.58 | 11.4 | 2.9 | 8.5 | 37.1 | 47 | 23 | 23 | 3 | 12 | 35 | 0 | 32 | 6 | 0 | 0 | 0 | 0 | 3.14 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 40 | 0 | 1 | 3 | 3.16 | .269 | 1.10 | 6.4 | 3.6 | 9.6 | 42.2 | 30 | 16 | 15 | 6 | 17 | 45 | 0 | 4 | 3 | 0 | 0 | 0 | 1 | 3.93 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 32 | 0 | 1 | 2 | 2.18 | .277 | 1.09 | 6.3 | 3.5 | 7.9 | 33.0 | 23 | 9 | 8 | 3 | 13 | 29 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.79 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 20 | 0 | 0 | 0 | 5.31 | .307 | 1.33 | 8.1 | 4.1 | 11.3 | 20.1 | 18 | 12 | 12 | 2 | 9 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.15 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 22 | 0 | 1 | 1 | 5.09 | .310 | 1.35 | 9.4 | 2.7 | 11.0 | 23.0 | 24 | 14 | 13 | 4 | 7 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.74 |