| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 93 | 29 | 29 | 11 | 9 | 3.92 | .287 | 1.20 | 8.4 | 2.4 | 5.6 | 190.2 | 178 | 86 | 83 | 9 | 51 | 119 | 2 | 0 | 0 | 1 | 16 | 1 | 6 | 3.18 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 10 | 9 | 3.68 | .270 | 1.08 | 7.2 | 2.5 | 8.4 | 156.2 | 125 | 67 | 64 | 19 | 44 | 145 | 0 | 0 | 0 | 0 | 15 | 5 | 0 | 3.67 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 82 | 28 | 28 | 12 | 9 | 3.82 | .318 | 1.37 | 9.1 | 3.3 | 5.1 | 174.1 | 175 | 75 | 74 | 13 | 63 | 99 | 2 | 0 | 0 | 1 | 17 | 6 | 2 | 4.02 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 27 | 26 | 10 | 10 | 4.55 | .333 | 1.48 | 10.1 | 3.3 | 4.9 | 166.1 | 186 | 91 | 84 | 24 | 61 | 91 | 0 | 0 | 0 | 0 | 14 | 2 | 8 | 4.92 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 69 | 0 | 5 | 6 | 2.34 | .243 | 0.93 | 5.3 | 3.1 | 10.1 | 88.1 | 52 | 28 | 23 | 7 | 30 | 99 | 0 | 10 | 2 | 0 | 0 | 3 | 4 | 2.91 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 52 | 0 | 5 | 5 | 2.98 | .279 | 1.13 | 7.1 | 3.2 | 8.4 | 60.1 | 47 | 20 | 20 | 9 | 21 | 56 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 4.23 |
| RP | Percival, T.Percival, Troy # >> | 26 | 1995 | R | 83 | 35 | 0 | 2 | 3 | 4.45 | .322 | 1.42 | 6.8 | 6.2 | 6.8 | 32.1 | 24 | 19 | 16 | 6 | 22 | 24 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 23 | 0 | 0 | 1 | 4.30 | .330 | 1.43 | 6.3 | 6.7 | 7.8 | 23.0 | 16 | 11 | 11 | 3 | 17 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.30 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 27 | 0 | 1 | 1 | 1.99 | .258 | 1.01 | 5.5 | 3.8 | 7.0 | 31.2 | 19 | 8 | 7 | 1 | 13 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.23 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 17 | 0 | 1 | 1 | 6.46 | .382 | 1.84 | 12.2 | 4.5 | 6.1 | 62.2 | 84 | 48 | 45 | 5 | 31 | 42 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.24 |