| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 32 | 32 | 13 | 13 | 3.87 | .289 | 1.20 | 8.3 | 2.5 | 9.3 | 244.1 | 225 | 108 | 105 | 31 | 67 | 252 | 7 | 0 | 0 | 2 | 18 | 6 | 4 | 3.48 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 31 | 31 | 11 | 14 | 4.84 | .327 | 1.41 | 9.2 | 3.5 | 9.4 | 191.2 | 195 | 106 | 103 | 33 | 75 | 199 | 1 | 0 | 0 | 0 | 14 | 10 | 3 | 4.50 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 31 | 31 | 8 | 12 | 6.14 | .354 | 1.58 | 10.3 | 3.9 | 9.6 | 174.1 | 200 | 125 | 119 | 31 | 76 | 186 | 1 | 0 | 0 | 1 | 11 | 10 | 3 | 4.66 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 69 | 30 | 30 | 13 | 13 | 4.97 | .336 | 1.48 | 9.4 | 4.0 | 6.6 | 221.0 | 230 | 129 | 122 | 28 | 98 | 162 | 11 | 0 | 0 | 1 | 14 | 7 | 8 | 4.61 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 66 | 29 | 29 | 9 | 10 | 5.58 | .344 | 1.54 | 10.2 | 3.7 | 8.7 | 174.1 | 197 | 114 | 108 | 36 | 71 | 168 | 0 | 0 | 0 | 0 | 12 | 6 | 5 | 5.09 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 77 | 0 | 3 | 5 | 3.12 | .274 | 1.09 | 7.4 | 2.4 | 9.4 | 109.2 | 90 | 41 | 38 | 13 | 29 | 114 | 0 | 4 | 2 | 0 | 0 | 5 | 3 | 3.39 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 88 | 77 | 0 | 6 | 9 | 3.61 | .321 | 1.39 | 7.4 | 5.1 | 9.1 | 87.1 | 72 | 40 | 35 | 10 | 49 | 88 | 0 | 13 | 4 | 0 | 0 | 3 | 5 | 4.26 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 82 | 55 | 0 | 3 | 0 | 4.04 | .298 | 1.24 | 8.8 | 2.5 | 11.3 | 55.2 | 54 | 29 | 25 | 12 | 15 | 69 | 0 | 4 | 1 | 0 | 0 | 2 | 4 | 4.25 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 30 | 0 | 2 | 5 | 3.09 | .281 | 1.17 | 8.2 | 2.3 | 8.7 | 35.0 | 32 | 13 | 12 | 8 | 9 | 34 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.80 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 68 | 17 | 0 | 1 | 2 | 0.98 | .167 | 0.60 | 4.5 | 1.0 | 12.5 | 18.1 | 9 | 2 | 2 | 1 | 2 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.28 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 13 | 0 | 1 | 0 | 4.80 | .224 | 0.87 | 6.0 | 1.8 | 7.8 | 15.0 | 10 | 8 | 8 | 3 | 3 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.47 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 87 | 23 | 0 | 0 | 0 | 3.77 | .262 | 1.03 | 5.2 | 4.1 | 8.1 | 31.0 | 18 | 13 | 13 | 5 | 14 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.74 |