| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 97 | 31 | 31 | 15 | 8 | 3.18 | .256 | 1.00 | 6.5 | 2.6 | 9.3 | 218.0 | 157 | 80 | 77 | 33 | 62 | 225 | 1 | 0 | 0 | 1 | 25 | 6 | 5 | 3.84 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 30 | 30 | 11 | 11 | 5.14 | .334 | 1.50 | 9.6 | 3.9 | 9.5 | 199.2 | 212 | 116 | 114 | 32 | 87 | 211 | 3 | 0 | 0 | 0 | 15 | 1 | 4 | 4.30 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 75 | 30 | 30 | 14 | 13 | 4.22 | .294 | 1.22 | 7.9 | 3.1 | 6.5 | 226.1 | 199 | 108 | 106 | 33 | 78 | 162 | 17 | 0 | 0 | 3 | 15 | 6 | 7 | 4.58 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 30 | 30 | 9 | 14 | 5.58 | .329 | 1.45 | 9.4 | 3.7 | 6.3 | 214.1 | 223 | 136 | 133 | 36 | 88 | 150 | 7 | 0 | 0 | 1 | 8 | 4 | 9 | 5.07 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 74 | 0 | 5 | 5 | 2.53 | .254 | 1.01 | 5.6 | 3.5 | 8.3 | 96.0 | 60 | 28 | 27 | 10 | 37 | 88 | 0 | 16 | 6 | 0 | 0 | 1 | 2 | 3.71 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 76 | 52 | 0 | 7 | 3 | 3.60 | .283 | 1.15 | 6.3 | 4.1 | 9.8 | 60.0 | 42 | 24 | 24 | 9 | 27 | 65 | 0 | 6 | 1 | 0 | 0 | 2 | 3 | 4.23 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 75 | 32 | 0 | 7 | 0 | 2.52 | .276 | 1.07 | 5.8 | 3.9 | 9.9 | 39.1 | 25 | 13 | 11 | 2 | 17 | 43 | 0 | 2 | 2 | 0 | 0 | 3 | 5 | 3.00 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 72 | 24 | 0 | 1 | 2 | 3.00 | .277 | 1.15 | 7.3 | 3.0 | 7.7 | 27.0 | 22 | 9 | 9 | 3 | 9 | 23 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.74 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 22 | 0 | 0 | 2 | 6.14 | .347 | 1.55 | 10.2 | 3.7 | 8.6 | 22.0 | 25 | 15 | 15 | 4 | 9 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.82 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 6 | 0 | 0 | 1 | 6.48 | .390 | 1.92 | 13.5 | 4.5 | 6.8 | 8.1 | 12 | 6 | 6 | 0 | 4 | 6 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.00 |