| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 35 | 35 | 11 | 16 | 4.11 | .296 | 1.24 | 8.9 | 2.3 | 8.4 | 229.2 | 226 | 110 | 105 | 38 | 59 | 213 | 4 | 0 | 0 | 3 | 22 | 4 | 0 | 4.12 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 31 | 31 | 10 | 9 | 4.21 | .310 | 1.33 | 9.2 | 2.7 | 6.3 | 190.1 | 195 | 93 | 89 | 27 | 58 | 133 | 0 | 0 | 0 | 0 | 15 | 3 | 3 | 4.41 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 92 | 0 | 6 | 7 | 4.01 | .318 | 1.37 | 8.5 | 3.9 | 9.2 | 112.1 | 106 | 54 | 50 | 19 | 48 | 114 | 0 | 11 | 6 | 0 | 0 | 3 | 1 | 4.54 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 85 | 77 | 0 | 4 | 5 | 3.26 | .281 | 1.12 | 6.6 | 3.4 | 10.5 | 94.0 | 69 | 35 | 34 | 12 | 36 | 110 | 0 | 9 | 4 | 0 | 0 | 5 | 2 | 3.63 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 81 | 55 | 0 | 6 | 2 | 1.46 | .239 | 0.94 | 6.2 | 2.3 | 9.7 | 68.0 | 47 | 11 | 11 | 5 | 17 | 73 | 0 | 10 | 2 | 0 | 0 | 0 | 0 | 2.56 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 76 | 32 | 0 | 4 | 1 | 1.27 | .215 | 0.77 | 4.3 | 2.8 | 10.1 | 42.2 | 20 | 7 | 6 | 2 | 13 | 47 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.45 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 33 | 0 | 0 | 2 | 3.57 | .274 | 1.13 | 6.9 | 3.3 | 8.5 | 35.1 | 27 | 15 | 14 | 3 | 13 | 33 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3.34 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 60 | 33 | 0 | 5 | 0 | 2.76 | .250 | 0.98 | 6.1 | 2.8 | 10.8 | 49.0 | 33 | 16 | 15 | 9 | 15 | 59 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.96 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 57 | 6 | 0 | 2 | 1 | 3.00 | .333 | 1.50 | 9.0 | 4.5 | 7.5 | 6.0 | 6 | 5 | 2 | 2 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 7.17 |